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首页> 外文期刊>Journal of hypertension >A long-term moderate magnesium-deficient diet aggravates cardiovascular risks associated with aging and increases mortality in rats.
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A long-term moderate magnesium-deficient diet aggravates cardiovascular risks associated with aging and increases mortality in rats.

机译：长期中度缺镁饮食会加剧与衰老相关的心血管风险，并增加大鼠的死亡率。

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OBJECTIVE: The present study aimed to show whether long-term moderate magnesium (Mg)-deficient (150 mg/kg) and Mg-supplemented (3200 mg/kg) diets (versus control diet: 800 mg/kg), modified the occurrence of cardiovascular risk induced by aging in the rat. METHODS: Cardiovascular and arterial functions were determined by a systemic hemodynamic study and by ex vivo measurements of vasoconstriction and endothelium dependent-vasorelaxation. Arterial wall structure was determined using pressure myograph chamber and histomorphometric methods. RESULTS: The main changes observed in old rats (96 weeks old) fed a control diet, in comparison to adult rats (16 weeks old) were increased pulse pressure, a loss of aortic endothelium-dependent relaxation, increased aortic wall thickness and a decrease of the aortic wall elastin/collagen ratio. Long-term moderate Mg deficiency progressively increased systolic blood pressure. Intra-arterial pulse pressure was higher in Mg-deficient old rats than in age-matched control rats. Histological examination showed that Mg deficiency increased the age-induced deleterious effects on composition and structure of aorta (media thickness, increased collagen content and reduction in the elastin/collagen ratio), which lead to large artery rigidity. Hypertension and increased pulse pressure may have contributed to the increase in the mortality rate observed in the hypertensive Mg-deficient group. Although the long-term Mg-supplemented diet lowered blood pressure and decreased the mortality rate, it had no significant effect on aortic wall thickening and stiffening. CONCLUSION: It is suggested that a long-term and moderate Mg-deficient diet increases age-induced arterial thickness and stiffness in rats, and thus increases the cardiovascular risks incurred by aging.
机译：目的：本研究旨在显示长期中度缺镁（Mg）（150 mg / kg）和补充Mg（3200 mg / kg）的饮食（相对于对照饮食：800 mg / kg）是否能改变发生率大鼠衰老所致的心血管风险。方法：通过全身血流动力学研究以及离体测量血管收缩和内皮依赖性血管舒张来确定心血管和动脉功能。使用压力肌电图室和组织形态学方法确定动脉壁结构。结果：与成年大鼠（16周龄）相比，对照饮食的成年大鼠（96周龄）观察到的主要变化是脉压增加，主动脉内皮依赖性松弛丧失，主动脉壁厚度增加和降低主动脉壁的弹性蛋白/胶原蛋白比率。长期中度缺镁会逐渐增加收缩压。缺镁的老年大鼠的动脉内脉压高于年龄相匹配的对照大鼠。组织学检查表明，镁缺乏会增加年龄引起的对主动脉组成和结构的有害影响（培养基厚度增加，胶原蛋白含量增加以及弹性蛋白/胶原蛋白比降低），从而导致大的动脉僵硬度。高血压和脉压升高可能是导致高血压缺镁组死亡率增加的原因。尽管长期补充镁可降低血压并降低死亡率，但对主动脉壁增厚和僵硬没有明显影响。结论：建议长期中度缺镁饮食会增加大鼠年龄引起的动脉厚度和僵硬度，从而增加衰老引起的心血管疾病风险。

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