...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of hypertension >Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
【24h】

Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.

机译：妇女基因组健康研究：52个候选基因中77个多态性与血压升高和高血压的关联。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: Genetic risk factors for essential hypertension are largely unknown. The aim of the present study was to assess the association of 77 previously characterized gene variants in 52 candidate genes from various biological pathways with blood pressure (BP) progression and incident hypertension. METHODS: We analyzed data from 18 738 white women who participated in a prospective cohort study and were free of hypertension at baseline. BP progression at 48 months and incident hypertension during the entire follow-up according to the different genotypes were assessed by logistic regression and Cox proportional-hazards models, respectively. RESULTS: At 48 months of follow-up, 7889 of 16 635 women (47.4%) had BP progression. Only three of 70 polymorphisms with a minor allele frequency of at least 2% had a significant association with BP progression. The odds ratio [95% confidence interval (CI)] for 5,10-methylenetetrahydrofolate reductase (MTHFR) rs1801133 (minor allele T), natriuretic peptide precursor A (NPPA) rs5063 (minor allele A) and NPPA rs5065 (minor allele C) were 1.05 (1.00-1.10), 0.84 (0.76-0.94) and 0.93 (0.88-1.00), respectively. After adjustment for multiple testing using the false discovery rate, only the NPPA rs5063 association remained significant. During a median follow-up of 9.8 years, 5540 of 18 738 women developed incident hypertension. Only five of 70 polymorphisms were significantly associated with incident hypertension. The hazard ratio (95% CI) for interleukin 6 (IL-6) rs1800795 (minor allele C), MTHFR rs1801133, NPPA rs5063, nitric oxide synthase 3 rs1799983 (minor allele T) and transforming growth factor, beta 1 rs1800469 (minor allele T) were 0.96 (0.92-1.00), 1.06 (1.02-1.10), 0.88 (0.80-0.96), 1.05 (1.01-1.09) and 1.05 (1.01-1.10), respectively. After adjustment for multiple testing, none of these associations remained significant. CONCLUSION: NPPA gene polymorphisms may have a role in BP progression and incident hypertension. Our data also provide moderate confirmatory evidence of association between MTHFR rs1801133 and the development of hypertension.
机译：目的：原发性高血压的遗传危险因素尚不清楚。本研究的目的是评估来自各种生物学途径的52个候选基因中77个先前表征的基因变异与血压（BP）进展和高血压的关联。方法：我们分析了来自18 738名白人妇女的数据，这些妇女参加了一项前瞻性队列研究，并且基线时没有高血压。通过Logistic回归和Cox比例风险模型分别评估了48个月的BP进展和整个随访期间根据不同基因型的高血压事件。结果：在48个月的随访中，16 635名女性中有7889名（47.4％）出现了BP进展。在70个多态性中，只有三个等位基因频率至少为2％，与BP进展密切相关。 5,10-亚甲基四氢叶酸还原酶（MTHFR）rs1801133（次要等位基因T），利钠肽前体A（NPPA）rs5063（次要等位基因A）和NPPA rs5065（次要等位基因C）的比值比[95％置信区间（CI）]分别为1.05（1.00-1.10），0.84（0.76-0.94）和0.93（0.88-1.00）。在使用错误发现率对多个测试进行调整后，仅NPPA rs5063关联仍然很重要。在9.8年的中位随访期间，18 738名妇女中有5540名发生了突发性高血压。 70种多态性中只有5种与突发性高血压显着相关。白介素6（IL-6）rs1800795（次要等位基因C），MTHFR rs1801133，NPPA rs5063，一氧化氮合酶3 rs1799983（次要等位基因T）和转化生长因子，β1 rs1800469（次要等位基因）的危险比（95％CI） T）分别为0.96（0.92-1.00），1.06（1.02-1.10），0.88（0.80-0.96），1.05（1.01-1.09）和1.05（1.01-1.10）。在针对多个测试进行调整之后，这些关联均保持不变。结论：NPPA基因多态性可能与血压的升高和高血压的发生有关。我们的数据还提供了MTHFR rs1801133与高血压发展之间相关性的中度验证性证据。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号