• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of immunotherapy >Sequential administration of the native TERT572 cryptic peptide enhances the immune response initiated by its optimized variant TERT(572Y) in cancer patients.
【24h】

Sequential administration of the native TERT572 cryptic peptide enhances the immune response initiated by its optimized variant TERT(572Y) in cancer patients.

机译：天然TERT572隐性肽的顺序给药可增强其优化的变体TERT（572Y）对癌症患者的免疫应答。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aim of this study was to investigate the best administration of telomerase reverse transcriptase (TERT572), an human leukocyte antigen-A*0201-restricted cryptic epitope of telomerase, and its optimized variant TERT(572Y) to elicit specific T cell immune responses in cancer patients. Forty-eight cancer patients with chemo-resistant tumors received 2 subcutaneous injections of TERT(572Y) at 2 mg followed at random by 4 subcutaneous injections of either TERT572 or TERT(572Y) peptides at 2 mg every 3 weeks. Specific immune response was evaluated by interferon-gamma enzyme-linked immunosorbent spot. T cell responses after the sixth vaccination were detected more frequently (44% vs. 17%), and with higher number of peptide-specific reactive T cells (60 T cells/2 x 10(5) peripheral blood mononuclear cell vs. 10 T cells/2 x 10(5) peripheral blood mononuclear cell, P=0.04), and higher avidity in the patients who received 4 more vaccinations with the TERT572 peptide compared with patients who received only TERT(572Y) vaccinations. These results demonstrate that the best vaccination schedule involves first the administration of the optimized TERT(572Y) followed by the native TERT572 peptides in patients who are candidates for cancer immunotherapy.
机译：本研究的目的是研究端粒酶逆转录酶（TERT572），人白细胞抗原-A * 0201限制的端粒酶隐表位的最佳给药方法及其优化的变体TERT（572Y），以在小鼠中引发特异性T细胞免疫应答。癌症患者。患有化学耐药性肿瘤的四十八名癌症患者每2周接受2毫克2毫克的TERT（572Y）皮下注射，随后随机每3周进行2毫克2毫克的TERT572或TERT（572Y）肽皮下注射。通过干扰素-γ酶联免疫吸附点评估特异性免疫应答。第六次接种后的T细胞反应被检测到的频率更高（44％比17％），并且肽特异性反应性T细胞的数量更高（60 T细胞/ 2 x 10（5）外周血单核细胞比10 T与仅接受TERT（572Y）疫苗接种的患者相比，接受4种TERT572肽疫苗接种的患者的细胞数为2 x 10（5）个外周血单个核细胞，P = 0.04），并且亲和力更高。这些结果表明，最佳的疫苗接种计划首先涉及在癌症免疫疗法候选患者中施用优化的TERT（572Y），然后是天然TERT572肽。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号