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首页> 外文期刊>Journal of infection and chemotherapy: official journal of the Japan Society of Chemotherapy >A fatal infection caused by sequence type 398 methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin gene: A case report in Japan
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A fatal infection caused by sequence type 398 methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin gene: A case report in Japan

机译：携带潘顿-华伦天白蛋白基因的398型耐甲氧西林金黄色葡萄球菌序列引起的致命感染：日本的病例报告

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摘要

Methicillin-resistant Staphylococcus aureus (MRSA) has now been recognized as a common pathogen in the community. Sequence type (ST) 398 MRSA is generally considered as an emerging zoonotic agent spreading among livestock and personnel who have direct contact with animals, mainly in Europe. A 37-year-old Chinese woman receiving steroid therapy for systemic lupus erythematosus with general fatigue and myalgia was brought to the emergency department in critical condition. Her condition deteriorated despite aggressive management and she died on day 7. Her blood culture revealed ST398 MRSA-SCCmec V with Panton-Valentine Leukocidin (PVL) gene. This is the first case report of a fatal infection caused by this lineage. According to the results of molecular analyses, the isolate from this particular patient's blood was genetically close to a lineage detected in China, and is less likely to be related to an animal-associated lineage. (C) 2015, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
机译：耐甲氧西林金黄色葡萄球菌（MRSA）现在已被认为是社区中的常见病原体。序列类型（ST）398 MRSA通常被认为是一种新兴的人畜共患病病原体，主要分布在欧洲的家畜和与动物直接接触的人员中。一名接受全身性红斑狼疮伴全身性疲劳和肌痛的类固醇激素治疗的37岁中国妇女被送往急诊室，病情危重。尽管进行了积极的治疗，但她的病情恶化，并在第7天死亡。她的血液培养显示出具有Panton-Valentine Leukocidin（PVL）基因的ST398 MRSA-SCCmecV。这是该谱系引起的致命感染的首例病例报告。根据分子分析的结果，从该特定患者血液中分离得到的基因在遗传上接近中国检测到的谱系，与动物相关谱系的可能性较小。 （C）2015年，日本化学治疗学会和日本传染病协会。由Elsevier Ltd.出版。保留所有权利。

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