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首页> 外文期刊>Clinical nutrition >Cost containment through L-alanyl-L-glutamine supplemented total parenteral nutrition after major abdominal surgery: a prospective randomized double-blind controlled study.
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Cost containment through L-alanyl-L-glutamine supplemented total parenteral nutrition after major abdominal surgery: a prospective randomized double-blind controlled study.

机译：大型腹部手术后通过L-丙氨酰-L-谷氨酰胺补充总肠胃外营养来控制成本：一项前瞻性随机双盲对照研究。

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BACKGROUND & AIMS: Glutamine is recognized as a conditionally essential amino acid. Recent studies indicate that glutamine-containing total parenteral nutrition improves nitrogen economy, enhances gastrointestinal and immune functions and shortens hospital stay. METHODS: Thirty-seven patients (19 w and 18 m; age 61. 4+/-10.4 years; BMI 23.7+/-2.8 kg/m(2)) following major abdominal surgery receiving an isonitrogenous isoenergetic TPN with or without alanyl-glutamine supplementation (0.5 g/kg BW/day), were evaluated in a double-blind, randomized, controlled trial over a five-day period by measuring nitrogen balance, selected biochemical parameters and length of hospital stay. RESULTS: Supplemental alanyl-glutamine improved the overall mean (-3.5+/-1.6 vs. -5.5+/-1. 4 g N;P<0.05) and cumulative nitrogen balance (-14.1+/-9.1 vs. -21.7+/-11.4 g N;P<0.05) compared with the isonitrogenous, isoenergetic standard regimen. Alanyl-glutamine normalized plasma glutamine concentration and reduced the length of hospital stay (12.8+/-2.6 vs. 17.5+/-6.4 days;P<0.05). CONCLUSIONS: The results of the study confirm that supplementation with synthetic alanyl-glutamine dipeptide is associated with cost containment due to shortened hospitalization and improved nitrogen economy. Copyright 2000 Harcourt Publishers Ltd.
机译：背景与目的：谷氨酰胺被认为是有条件的必需氨基酸。最近的研究表明，含谷氨酰胺的全胃肠外营养改善了氮的经济性，增强了胃肠道和免疫功能，并缩短了住院时间。方法：大腹部手术后的37例患者（19 w和18 m;年龄61. 4 +/- 10.4岁; BMI 23.7 +/- 2.8 kg / m（2））在接受或不接受丙氨酰的情况下接受了等氮的等能量TPN通过测量氮平衡，选定的生化参数和住院时间，在为期五天的双盲，随机，对照试验中评估了补充谷氨酰胺（0.5 g / kg体重/天）。结果：补充的丙氨酰谷氨酰胺改善了总体平均值（-3.5 +/- 1.6对-5.5 +/- 1。4 g N; P <0.05）和累积氮平衡（-14.1 +/- 9.1对-21.7+ /-11.4 g N; P <0.05）与等氮，等能标准方案相比。丙氨酰-谷氨酰胺使血浆谷氨酰胺浓度正常化并缩短了住院时间（12.8 +/- 2.6天与17.5 +/- 6.4天; P <0.05）。结论：研究结果证实，由于缩短了住院时间并改善了氮的经济性，合成的丙氨酰-谷氨酰胺二肽的补充与成本控制有关。版权所有2000 Harcourt Publishers Ltd.。

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