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首页> 外文期刊>Biomolecules & therapeutics >Anti-Inflammatory Effect of Quercetagetin, an Active Component of Immature Citrus unshiu, in HaCaT Human Keratinocytes
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Anti-Inflammatory Effect of Quercetagetin, an Active Component of Immature Citrus unshiu, in HaCaT Human Keratinocytes

机译：槲皮素（未成熟的柑桔的活性成分）对HaCaT人角质形成细胞的抗炎作用

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摘要

Citrus fruit contain various flavonoids that have multiple biological activities. However, the content of these flavonoids are changed during maturation and immature Citrus is known to contain larger amounts than mature. Chemokines are significant mediators for cell migration, while thymus and activation-regulated chemokine (TARC/CCL17) and macrophage-derived chemokine (MDC/ CCL22) are well known as the typical inflammatory chemokines in atopic dermatitis (AD), a pruritic and chronic inflammatory skin disease. We reported recently that the EtOH extract of immature Citrus unshiu inhibits TARC and MDC production. Therefore, we investigated the activity of flavonoids contained in immature Citrus on TARC and MDC levels. As a result, among the various flavonoids, quercetagetin has stronger inhibitory effects on the protein and mRNA expression of TARC and MDC than other flavonoids. Quercetagetin particularly has better activity on TARC and MDC level than quercetin. In HPLC analysis, the standard peak of quercetagetin matches the peaks of extract of immature C. unshiu. This suggests that quercetagetin is an anti-inflammatory component in immature C. unshiu.
机译：柑橘类水果含有各种具有多种生物活性的类黄酮。但是，这些类黄酮的含量在成熟过程中会发生变化，已知不成熟的柑橘中的类黄酮含量要比成熟时大。趋化因子是细胞迁移的重要介质，而胸腺和活化调节趋化因子（TARC / CCL17）和巨噬细胞衍生趋化因子（MDC / CCL22）是特应性皮炎（AD），瘙痒和慢性炎症的典型炎症趋化因子。皮肤病。我们最近报道，未成熟的柑桔的EtOH提取物抑制TARC和MDC的产生。因此，我们研究了未成熟柑橘中黄酮类化合物在TARC和MDC水平上的活性。结果，在各种类黄酮中，槲皮素对TARC和MDC的蛋白质和mRNA表达具有比其他类黄酮更强的抑制作用。槲皮素在槲皮素和MDC水平上的活性特别强于槲皮素。在HPLC分析中，槲皮素的标准峰与未成熟梭状芽胞杆菌提取物的峰相匹配。这表明槲皮素是未成熟的梭状芽胞杆菌的抗炎成分。

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