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首页> 外文期刊>Biomolecules & therapeutics >6-O-Galloylpaeoniflorin Protects Human Keratinocytes Against Oxidative Stress-Induced Cell Damage
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6-O-Galloylpaeoniflorin Protects Human Keratinocytes Against Oxidative Stress-Induced Cell Damage

机译：6-O-加洛佩宁酸花青素保护人类角质形成细胞免受氧化应激诱导的细胞损伤

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摘要

6'-O-galloylpaeoniflorin (GPF) is a galloylated derivate of paeoniflorin and a key chemical constituent of the peony root, a perennial flowering plant that is widely used as an herbal medicine in East Asia. This study is the first investigation of the cytoprotective effects of GPF against hydrogen peroxide (H_2O_2)-induced cell injury and death in human HaCaT keratinocytes. GPF demonstrated a significant scavenging capacity against the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical, H_2O_2-generated intracellular reactive oxygen species (ROS), the superoxide anion radical (O2), and the hydroxyl radical ('OH). GPF also safeguarded HaCaT keratinocytes against H_2O_2-provoked apoptotic cell death and attenuated oxidative macromolecular damage to DNA, lipids, and proteins. The compound exerted its cytoprotective actions in keratinocytes at least in part by decreasing the number of DNA strand breaks, the levels of 8-isoprostane (a stable end-product of lipid peroxidation), and the formation of carbonylatedprotein species. Taken together, these results indicate that GPF may be developed as a cytoprotector against ROS-mediated oxidative stress.
机译：6'-O-galloylpaeoniflorin（GPF）是pa药苷的没食子酸酯化衍生物，是牡丹根的重要化学成分，牡丹是多年生开花植物，在东亚被广泛用作草药。这项研究是GPF对过氧化氢（H_2O_2）诱导的人HaCaT角质形成细胞损伤和死亡的细胞保护作用的首次研究。 GPF表现出对1,1-二苯基-2-吡啶并肼基（DPPH）自由基，H_2O_2生成的细胞内活性氧（ROS），超氧阴离子自由基（O2）和羟基自由基（'OH）的清除能力。 GPF还保护HaCaT角质形成细胞免受H_2O_2引起的凋亡，并减轻对DNA，脂质和蛋白质的氧化性大分子损伤。该化合物至少部分地通过减少DNA链断裂的数量，8-异前列腺素的水平（脂质过氧化作用的稳定终产物）和形成羰基化的蛋白质而在角质形成细胞中发挥其细胞保护作用。两者合计，这些结果表明，GPF可能被开发为抵抗ROS介导的氧化应激的细胞保护剂。

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