Methylated beta-cyclodextrin as P-gp modulators for deliverance of doxorubicin across an in vitro model of blood-brain barrier.

Tilloy S; Monnaert V; Fenart L; Bricout H; Cecchelli R; Monflier E

首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >Methylated beta-cyclodextrin as P-gp modulators for deliverance of doxorubicin across an in vitro model of blood-brain barrier.

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Methylated beta-cyclodextrin as P-gp modulators for deliverance of doxorubicin across an in vitro model of blood-brain barrier.

机译：甲基化的β-环糊精作为P-gp调节剂，可在体外血脑屏障模型中递送阿霉素。

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Co-incubations of various beta-cyclodextrins and doxorubicin have been evaluated on an in vitro model of blood-brain barrier in order to increase the delivery of this P-gp substrate to the brain. Among these cyclodextrins used, the Rame-beta-cyclodextrin and Crysme-beta-cyclodextrin increased the transport by a factor of 2 and 3.7, respectively. This increase was attributed to the cholesterol extraction property of these cyclodextrins from brain capillary endothelial cells leading to a modulation of the P-gp activity.

机译：为了增加这种P-gp底物向大脑的输送，已经在血脑屏障的体外模型中评估了各种β-环糊精和阿霉素的共培养。在使用的这些环糊精中，Rame-β-环糊精和Crysme-β-环糊精分别将转运提高了2倍和3.7倍。这种增加归因于这些环糊精从脑毛细血管内皮细胞中提取胆固醇的特性，从而导致P-gp活性的调节。

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《Bioorganic and Medicinal Chemistry Letters》 |2006年第8期|共4页
作者
Tilloy S; Monnaert V; Fenart L; Bricout H; Cecchelli R; Monflier E;
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正文语种 eng
中图分类药学;生物化学;
关键词
Blood-Brain Barrier; Doxorubicin; Endothelial Cells; P-Glycoproteins; beta-Cyclodextrins; 血脑屏障; 阿霉素; P糖蛋白类;

机译：Blood-Brain Barrier;Doxorubicin;Endothelial Cells;P-Glycoproteins;beta-Cyclodextrins;血脑屏障;阿霉素;P糖蛋白类;

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1. Methylated beta-cyclodextrin as P-gp modulators for deliverance of doxorubicin across an in vitro model of blood-brain barrier. [J] . Tilloy S, Monnaert V, Fenart L, Bioorganic and Medicinal Chemistry Letters . 2006,第8期

机译：甲基化的β-环糊精作为P-gp调节剂，可在体外血脑屏障模型中递送阿霉素。
2. Transport of a GABAA receptor modulator and its derivatives from Valeriana officinalis L. s. l. across an in vitro cell culture model of the blood-brain barrier. [J] . Neuhaus W, Trauner G, Gruber D, Planta medica: Natural products and medicinal plant research . 2008,第11期

机译：缬草的GABAA受体调节剂及其衍生物的转运。 l。跨血脑屏障的体外细胞培养模型。
3. Basic fibroblast growth factor modulates density of blood vessels and preserves tight junctions in organotypic cortical cultures of mice: a new in vitro model of the blood-brain barrier. [J] . Bendfeldt K, Radojevic V, Kapfhammer J, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2007,第12期

机译：碱性成纤维细胞生长因子调节小鼠血管的密度，并在小鼠器官型皮质培养物中保持紧密连接：血脑屏障的新型体外模型。
4. Fondaparinux Sodium (Arixtra~R) Does Not Cross the Placental Barrier. Study Using the In Vitro Human Dually-Perfused Cotyledon Model [C] . F. Lagrange, F. Paolucci, C. Vergnes, European Haematology Association . 2002

机译：Fondaparinux钠（Arixtra〜R）不会越过胎盘屏障。使用体外人类双重灌注的子叶模型进行研究
5. A microfluidic in vitro model of the blood-brain barrier. [D] . Booth, Ross Hunter. 2014

机译：血脑屏障的微流体外模型。
6. PCM-11MORPHINE MODULATES DOXORUBICIN UPTAKE: CYTOFLUORIMETRIC STUDY ON AN IN VITRO MODEL OF BLOOD-BRAIN BARRIER [O] . Anna Lisa Iorio, Martina Da Ros, Maurizio Lucchesi, 2016

机译：PCM-11吗啡调节阿霉素的摄取：血脑屏障体外模型的细胞荧光研究
7. The Use of Microdialysis Techniques in Mice to Study P-gp Function at the Blood-Brain Barrier. [O] . Sziráki, István, Erdő, Franciska, Trampus, Péter, 2013

机译：在小鼠中使用微透析技术研究血脑屏障的P-gp功能。

Methylated beta-cyclodextrin as P-gp modulators for deliverance of doxorubicin across an in vitro model of blood-brain barrier.

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