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首页> 外文期刊>Journal of human nutrition and dietetics >The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial
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The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial

机译:磷脂酰丝氨酸给药对注意力缺陷多动障碍的记忆和症状的影响:一项随机,双盲,安慰剂对照的临床试验

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Background Attention-deficit hyperactivity disorder (ADHD) is the most commonly diagnosed behavioural disorder of childhood, affecting 3–5% of school-age children. The present study investigated whether the supplementation of soy-derived phosphatidylserine (PS), a naturally occurring phospholipid, improves ADHD symptoms in children. Methods Thirty six children, aged 4–14?years, who had not previously received any drug treatment related to ADHD, received placebo (n?=?17) or 200?mg?day–1 PS (n?=?19) for 2?months in a randomised, double-blind manner. Main outcome measures included: (i) ADHD symptoms based on DSM-IV-TR; (ii) short-term auditory memory and working memory using the Digit Span Test of the Wechsler Intelligence Scale for Children; and (iii) mental performance to visual stimuli (GO/NO GO task). Results PS supplementation resulted in significant improvements in: (i) ADHD (P?
机译:背景注意缺陷多动障碍(ADHD)是儿童中最常见的被诊断为行为障碍,影响了3-5%的学龄儿童。本研究调查了补充大豆衍生的磷脂酰丝氨酸(PS)(一种天然存在的磷脂)是否可以改善儿童的ADHD症状。方法36名4-14岁的儿童以前未接受过与多动症相关的药物治疗,接受了安慰剂(n?=?17)或200 mg?day-1 PS(n?=?19)治疗。以随机双盲方式进行2个月。主要结果指标包括:(i)基于DSM-IV-TR的ADHD症状; (ii)使用儿童韦氏智力量表的数字跨度测试进行短期听觉记忆和工作记忆; (iii)对视觉刺激的心理表现(执行/不执行任务)。结果PS补充剂显着改善了:(i)ADHD(P 0.01),AD(P 0.01)和HD(P 0.01); (ii)短期听觉记忆(P <0.05); (iii)注意力不集中(分化和逆向分化,P <0.05)和注意力不集中和冲动(P <0.05)。在其他测量和安慰剂组中未观察到显着差异。 PS具有良好的耐受性,并且没有不良反应。结论PS可以明显改善儿童的ADHD症状和短期听觉记忆。补充PS可能是一种安全,天然的营养策略,可以改善患有ADHD的幼儿的心理表现。

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