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首页> 外文期刊>Journal of human nutrition and dietetics >Use of sibutramine to assist obese women with weight loss can be successful in dietitian-led clinics: another tool in the dietitian's toolbox.
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Use of sibutramine to assist obese women with weight loss can be successful in dietitian-led clinics: another tool in the dietitian's toolbox.

机译：在营养师主导的诊所中，使用西布曲明协助肥胖的女性减肥是成功的：这是营养师工具箱中的另一种工具。

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BACKGROUND: This study investigated differences in weight loss outcomes in obese women with Type 2 diabetes (T2D) compared to those without T2D attending a 6-month dietetic led 'Lifestyle' intervention. In those who had failed to reach weight loss goals using the 'Lifestyle' approach, the study further examined the effect on weight loss with the addition of sibutramine (Reductil, Abbott Laboratories, USA) over a 6-month period. METHODS: The study comprised a case-control analysis of data from 38 obese female patients (18 with T2D) from the 'Lifestyle' and 'Pharmacotherapy' clinics attending a tertiary hospital in the UK. RESULTS: In the 'Lifestyle' treatment groups, those with T2D lost significantly less body weight than those without T2D [5.26 kg (4.54%) versus 9.89 kg (9.55%), respectively]. For subjects who had failed to lose weight via the 'Lifestyle' intervention, the addition of sibutramine resulted in a similar weight loss compared to their pair-matched 'Lifestyle' only 'successful' counterparts(9.66% versus 9.55%). CONCLUSIONS: Not all obese women, and those with T2D in particular, will derive benefit from 'Lifestyle' advice and those who are resistant to this treatment approach may be assisted by pharmacotherapy. Dietitians can play a role in identifying those individuals who may benefit from the use of pharmacotherapy.
机译：背景：本研究调查了患有2型糖尿病（T2D）的肥胖女性与未参加6个月饮食指导的“生活方式”干预的肥胖女性相比，减肥效果的差异。在那些未能通过“生活方式”方法实现减肥目标的人群中，该研究进一步研究了在6个月的时间内添加西布曲明（Reductil，Abbott Laboratories，美国）对减肥的影响。方法：该研究包括对来自英国一家三级医院的“生活方式”和“药物疗法”诊所的38例肥胖女性患者（18例T2D）的数据进行病例对照分析。结果：在“生活方式”治疗组中，患有T2D的人的体重显着低于未患有T2D的人[分别为5.26 kg（4.54％）和9.89 kg（9.55％）]。对于通过“生活方式”干预未能减肥的受试者，西布曲明的添加与配对的“生活方式”仅“成功”的受试者相比导致相似的体重减轻（9.66％对9.55％）。结论：并非所有肥胖女性，特别是患有T2D的女性，都会从“生活方式”建议中受益，并且对这种治疗方法有抵抗力的女性可能会接受药物治疗。营养师可以在确定那些可能受益于药物治疗的个体中发挥作用。

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