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首页> 外文期刊>Journal of immunoassay >Serum thyroxine binding capacity-dependent bias in an automated free thyroxine assay.
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Serum thyroxine binding capacity-dependent bias in an automated free thyroxine assay.

机译：在自动化的免费甲状腺素测定中，血清甲状腺素结合能力依赖性偏倚。

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摘要

The magnitude of serum thyroxine (T4) binding capacity (sBC) dependent bias in the AXSYM free thyroxine (FT4) assay was assessed using two recently described tests. One of the tests uses a direct equilibrium dialysis (ED) FT4 assay as the reference method. The results obtained with the AXSYM method were compared with those obtained by the ED FT4 method in patient sera having a wide range of sBC. The other test involves comparison of the FT4 results obtained following dilution of sera by an inert buffer, to theoretically derived FT4 results. As serum dilution causes a predictable decrease in sBC, the demonstration of a negative bias whose magnitude increases in parallel to the dilution, is indicative of an sBC-dependent bias. The AXSYM FT4 assay exhibited a significant sBC-dependent bias. This sBC-dependent bias is likely to have been caused by the presence of significant amounts of T4 binding proteins in the assay reagents.
机译：使用最近描述的两项测试评估了无AXSYM甲状腺素（FT4）分析中血清甲状腺素（T4）结合能力（sBC）依赖性偏倚的程度。其中一项测试使用直接平衡透析（ED）FT4分析作为参考方法。将AXSYM方法获得的结果与ED FT4方法获得的结果在具有广泛sBC的患者血清中进行了比较。另一个测试涉及将惰性缓冲液稀释血清后获得的FT4结果与理论上得出的FT4结果进行比较。由于血清稀释会导致可预测的sBC降低，因此负偏倚的显示与稀释平行地增加，这表明存在sBC依赖性偏倚。 AXSYM FT4分析显示出明显的sBC依赖性偏倚。这种sBC依赖性偏倚可能是由于测定试剂中存在大量的T4结合蛋白引起的。

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