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首页> 外文期刊>Journal of Infection >Apoptosis markers soluble Fas (sFas), Fas Ligand (FasL) and sFas/FasL ratio in patients with bacteremia: A prospective cohort study
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Apoptosis markers soluble Fas (sFas), Fas Ligand (FasL) and sFas/FasL ratio in patients with bacteremia: A prospective cohort study

机译：细菌血症患者中凋亡标志物可溶性Fas（sFas），Fas Ligand（FasL）和sFas / FasL比值的前瞻性队列研究

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Background: Recent studies have shown that immunoparalysis and lymphocyte apoptosis play a critical role in severe bacteremia. Monitoring apoptosis on a routine basis in septic patients has proved challenging. We here studied the prognostic value of apoptosis markers human soluble Fas (sFas), Fas ligand (FasL) and sFas/FasL ratio in patients with bacteremia. Methods: sFas (ng/ml) and FasL (ng/ml) concentrations in plasma were determined using commercial quantitative enzyme immunoassays (Quantikine?, R&D Systems Inc., Minneapolis, MN, USA) in 132 patients with bacteremia caused by Staphylococcus aureus, Streptococcus pneumoniae, β-hemolytic streptococcae or Escherichia coli. Results: Maximum sFas, minimum FasL and high sFas/FasL ratio predicted high SOFA score in bacteremic patients (p0.001, p=0.003 and p0.001, respectively). AUC ROC's in the prediction of high SOFA score for sFas, FasL and sFas/FasL ratio were 0.70 (CI 0.61-0.79), 0.65 (CI 0.56-0.75) and 0.72 (CI 0.63-0.80), respectively. High sFas concentrations and sFas/aFasL ratio, assessed using ROC curve as regards high SOFA (≥4) score, were associated with hypotension (p=0.001 and p=0.039, respectively). All of these markers predicted a high SOFA score independently in a logistic regression model. Maximum sFas, sFas/FasL ratio or minimum FasL during days 1-4 after blood culture were not associated with increased case fatality. Conclusions: Apoptosis markers sFas, FasL or sFas/FasL ratio are associated with high SOFA score in bacteremia.
机译：背景：最近的研究表明，免疫麻痹和淋巴细胞凋亡在严重菌血症中起关键作用。在败血症患者中常规监测细胞凋亡已被证明具有挑战性。我们在这里研究了凋亡标记物人类可溶性Fas（sFas），Fas配体（FasL）和sFas / FasL比在细菌血症患者中的预后价值。方法：采用商业定量酶免疫法（Quantikine？，R＆D Systems Inc.，美国明尼苏达州明尼苏达州，明尼苏达州，明尼苏达州，R＆D Systems Inc.）测定血浆中sFas（ng / ml）和FasL（ng / ml）的浓度，肺炎链球菌，β-溶血性链球菌或大肠杆菌。结果：细菌患者的最大sFas，最小FasL和高sFas / FasL比值预示了SOFA评分较高（分别为p <0.001，p = 0.003和p <0.001）。预测sFas，FasL和sFas / FasL比的高SOFA分数的AUC ROC分别为0.70（CI 0.61-0.79），0.65（CI 0.56-0.75）和0.72（CI 0.63-0.80）。对于高SOFA（≥4）评分，使用ROC曲线评估的高sFas浓度和sFas / aFasL比与低血压相关（分别为p = 0.001和p = 0.039）。所有这些标记均在逻辑回归模型中独立预测了较高的SOFA得分。血液培养后第1-4天的最大sFas，sFas / FasL比或最小FasL与病死率增加无关。结论：凋亡标志物sFas，FasL或sFas / FasL比值与菌血症中SOFA评分高有关。

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