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首页> 外文期刊>Journal of health science. >Effect of Sodium Selenite Supplementation on Glucose Intolerance and Pancreatic Oxidative Stress in Type 2 Diabetic Mice under Different Selenium Status
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Effect of Sodium Selenite Supplementation on Glucose Intolerance and Pancreatic Oxidative Stress in Type 2 Diabetic Mice under Different Selenium Status

机译：不同硒状态下亚硒酸钠对2型糖尿病小鼠糖耐量及胰腺氧化应激的影响

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摘要

The objective of this study was to investigate the effect of various selenium (Se) status on glucose intolerance and pancreatic oxidative stress or the defense systems in Nagoya-Shibata-Yasuda (NSY) mice as the animal model for type 2 diabetes mellitus. To let the mice become Se-insufficient to Se-sufficient conditions, the NSY mice were given normal or Se-deficient diet with 0-7.0 mg/1 Na_2SeO_3-containing drinking water for 6, 8 or 12 weeks. In NSY mice ingested normal diet, levels of blood glucose and plasma insulin after intraperitoneal glucose tolerance test (IPGTT) were not significantly affected by Na2SeO3-supplementation. In Se-deficient diet-treatment groups, however, the supplementation resulted in the decrease of blood glucose and the increase of plasma insulin after IPGTT. Although glutathione peroxidase (GPX) 1 activity in pancreas of the NSY mice ingested Se-deficient diet was augmented by Na_2SeO_3 -supplementation, pancreatic glutathione was depressed by the supplementation, accompanying by the increase of 2-thiobarbituric acid-reactive substances. These results indicated that although the supplemented Na_2SeO_3 may not protect against oxidative stress in the pancreas of NSY mice under Se-insufficient condition, the Se compound improved glucose intolerance of the mice.
机译：这项研究的目的是研究名古屋-柴田-安田（NSY）小鼠作为2型糖尿病动物模型时，各种硒（Se）状态对葡萄糖耐受不良和胰腺氧化应激或防御系统的影响。为了使小鼠变得硒不足而不能满足硒充足的条件，给NSY小鼠正常饮食或缺硒饮食，并在0至7.0 mg / 1 Na_2SeO_3的饮用水中饮食6、8或12周。在摄入正常饮食的NSY小鼠中，补充Na2SeO3不会显着影响腹膜内葡萄糖耐量试验（IPGTT）后的血糖和血浆胰岛素水平。然而，在硒缺乏饮食治疗组中，补充导致IPGTT后血糖降低和血浆胰岛素升高。尽管Na_2SeO_3-补充增加了缺硒饮食的NSY小鼠胰腺中的谷胱甘肽过氧化物酶（GPX）1活性，但补充谷胱甘肽却降低了谷胱甘肽过氧化物，伴随着2-硫代巴比妥酸反应性物质的增加。这些结果表明，尽管补充的Na_2SeO_3在硒不足的条件下不能保护NSY小鼠胰腺中的氧化应激，但是硒化合物改善了小鼠的葡萄糖耐量。

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