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首页> 外文期刊>Journal of Insect Physiology >Circadian regulation of egg-laying behavior in fruit flies Drosophila melanogaster
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Circadian regulation of egg-laying behavior in fruit flies Drosophila melanogaster

机译：昼夜节律对果蝇产卵行为的控制

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摘要

Significant progress has been made in our understanding of the neurogenetics of circadian clocks in fruit flies Drosophila melanogaster. Several pacemaker neurons and clock genes have now been identified and their roles in the cellular and molecular clockwork established. Some recent findings suggest that the basic architecture of the clock is multi-oscillatory; the clock mechanisms in the ventral lateral neurons (LN(v)s) of the fly brain govern locomotor activity and adult emergence rhythms, while the peripheral oscillators located in antennal cells regulate olfactory rhythm. Among circadian phenomena exhibited by Drosophila, the egg-laying rhythm is unique in many ways: (i) this rhythm persists under constant light (LL), while locomotor activity and adult emergence become arrhythmic, (ii) its circadian periodicity is much longer than 24h, and (iii) while egg-laying is rhythmic under constant darkness, the expression of two core clock genes period (per) and timeless (tim), is non-oscillatory in the ovaries. In this paper, we review our current knowledge of the circadian regulation of egg-laying behavior in Drosophila, and provide some possible explanations for its self-sustained nature. We conclude by discussing the existing limitations in our understanding of the regulatory mechanisms and propose few approaches to address them.
机译：在我们了解果蝇果蝇昼夜节律的神经遗传学方面取得了重大进展。现在已经鉴定出几种起搏器神经元和时钟基因，并确定了它们在细胞和分子时钟中的作用。最近的一些发现表明时钟的基本架构是多振荡的。苍蝇大脑腹侧外侧神经元（LN（v）s）的时钟机制控制运动活动和成年后出现的节律，而位于触角细胞中的外围振荡器则调节嗅觉节律。在果蝇表现出的昼夜节律现象中，产卵节律在许多方面都是独特的：（i）这种节律在恒定光照（LL）下持续存在，而运动活动和成年后出现心律失常，（ii）其节律周期长于第24小时，以及（iii）在持续黑暗中产卵有节律的同时，两个核心时钟基因的表达（per）和timeless（tim）在卵巢中无振荡。在本文中，我们回顾了我们目前对果蝇产卵行为的昼夜节律调控的知识，并为其自我维持的性质提供了一些可能的解释。最后，我们讨论了对监管机制的理解中存在的局限性，并提出了解决这些局限性的方法。

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