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首页> 外文期刊>Journal of Inorganic Biochemistry: An Interdisciplinary Journal >Low-dimensional compounds containing bioactive ligands. V: Synthesis and characterization of novel anticancer Pd(II) ionic compounds with quinolin-8-ol halogen derivatives
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Low-dimensional compounds containing bioactive ligands. V: Synthesis and characterization of novel anticancer Pd(II) ionic compounds with quinolin-8-ol halogen derivatives

机译：含有生物活性配体的低维化合物。 V：喹啉-8-醇卤素衍生物的新型抗癌Pd（II）离子化合物的合成与表征

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摘要

Three novel palladium(II) complexes, NH_2(CH_3)_2[PdCl_2(CQ)] (1) (CQ = 5-chloro-7-iodo-quinolin-8-ol), NH_2(CH_3)_2[PdCl_2(dClQ)] (2) (dClQ = 5,7-dichloro-quinolin-8-ol) and NH_2(CH_3)_2[PdCl_2(dBrQ)] (3) (dBrQ = 5,7-dibromo-quinolin-8-ol) have been prepared and characterized. Their structures contain square-planar [PdCl_2(XQ)]~? complex anions inwhich deprotonatedXQ ligands are coordinated to the Pd atoms via the pyridine nitrogen and the phenolato oxygen atoms, other two cis-positions are occupied by two chlorido ligands. Negative charges of these anions are balanced by uncoordinated dimethylammonium cations. Coordination of the XQ ligands to Pd(II) atom was confirmed by the differences in the stretching ν(OH) and ν(C=N) vibrations in the IR spectra of ligands and prepared complexes while bands of aliphatic CH and NH stretching vibrations observed in the spectra of 1-3 confirm the presence of dimethylammonium cations in the complexes. The binding of complexes 1-3 to calf thymus DNA was investigated using UV-visible and fluorescence emission spectrophotometry. The fluorescence spectral results indicate that the complexes can bind to DNA through an intercalative mode. The Stern-Volmer quenching constants obtained from the linear quenching plot are in the 1.04 × 10~4 to 4.35 × 10~4 M~(?1) range. The complexes exhibit significant anticancer activity tested on A2780 cells and cisplatin resistant cell line A2780/CP.
机译：三种新型钯（II）配合物NH_2（CH_3）_2 [PdCl_2（CQ）]（1）（CQ = 5-氯-7-碘-喹啉-8-ol），NH_2（CH_3）_2 [PdCl_2（dClQ） ]（2）（dClQ = 5,7-二氯喹啉-8-ol）和NH_2（CH_3）_2 [PdCl_2（dBrQ）]（3）（dBrQ = 5,7-二溴喹啉-8-ol）具有已经准备好并进行了特征化。它们的结构包含方形[PdCl_2（XQ）]〜？复杂的阴离子，其中去质子化的XQ配体通过吡啶氮和酚基氧原子与Pd原子配位，另外两个顺式位置被两个氯代配体占据。这些阴离子的负电荷由未配位的二甲基铵阳离子平衡。 XQ配体与Pd（II）原子的配位由配体和制备的配合物的IR光谱中的ν（O H）和ν（C = N）拉伸振动的差异证实，而脂肪族C H和在1-3的光谱中观察到的N H拉伸振动证实了配合物中存在二甲基铵阳离子。使用紫外可见光和荧光发射分光光度法研究了配合物1-3与小牛胸腺DNA的结合。荧光光谱结果表明，该复合物可以通过嵌入模式与DNA结合。由线性淬灭曲线得到的斯特恩-沃尔默淬灭常数在1.04×10〜4至4.35×10〜4M〜（Δ1）的范围内。该复合物对A2780细胞和顺铂耐药细胞系A2780 / CP具有显着的抗癌活性。

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