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首页> 外文期刊>Journal of Inorganic Biochemistry: An Interdisciplinary Journal >Factors affecting the aluminium content of human femoral head and neck
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Factors affecting the aluminium content of human femoral head and neck

机译：影响人股骨头和颈部铝含量的因素

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摘要

Tissues for the study were obtained intraoperatively during hip replacement procedures from 96 patients. In all the cases, the indication for this treatment was primary or secondary degenerative changes in the hip joint. The subject of the study was the head and neck of the femur, resected in situ. Aluminium concentrations measured in femoral head and neck samples from patients aged between 25 and 91 were varied. Statistical methods were applied to determine the variations in relation to the parameters from the background survey. Significant differences in the aluminium content of femoral head samples were observed between patients under and over 60 years of age. Based on the results, it was confirmed that the aluminium accumulates in bones over a lifetime. The study showed that the content of aluminium in the head and neck of the femur depends on the factors such as: type of medicines taken, contact with chemicals at work, differences in body anatomy and sex. The study on the levels of aluminium in bones and the factors affecting its concentration is a valuable source of information for further research on the role of aluminium in bone diseases. Based on the investigations, it was found that the GF-AAS technique is the best analytical tool for routine analysis of aluminium in complex matrix samples. The use of femoral heads in the investigations was approved by the Bioethics Committee of the University of Medical Sciences in Poznan (Poland). (C) 2015 Elsevier Inc. All rights reserved.
机译：本研究的组织是在髋关节置换手术过程中从96例患者中获得的。在所有情况下，该治疗的适应症是髋关节的原发性或继发性退行性改变。该研究的对象是股骨的头和颈部，原位切除。 25岁至91岁患者的股骨头和颈部样品中测得的铝浓度各不相同。应用统计方法确定与背景调查相关的参数变化。在60岁以下及60岁以上的患者之间观察到股骨头铝含量的显着差异。根据该结果，可以确认铝在整个寿命中都在骨骼中积聚。研究表明，股骨头部和颈部的铝含量取决于以下因素：服用的药物类型，工作中与化学物质的接触，身体解剖结构和性别的差异。对骨骼中铝含量及其影响因素的研究为进一步研究铝在骨骼疾病中的作用提供了有价值的信息来源。在调查的基础上，发现GF-AAS技术是常规分析复杂基质样品中铝的最佳分析工具。波兹南（波兰）医学科学大学生物伦理委员会批准在研究中使用股骨头。 （C）2015 Elsevier Inc.保留所有权利。

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