The adsorption of allergoids and 3-O-desacyl-4 '-monophosphoryl lipid A (MPL (R)) to microcrystalline tyrosine (MCT) in formulations for use in allergy immunotherapy

Bell A. J.; Heath M. D.; Hewings S. J.; Skinner M. A.

首页> 外文期刊>Journal of Inorganic Biochemistry: An Interdisciplinary Journal >The adsorption of allergoids and 3-O-desacyl-4 '-monophosphoryl lipid A (MPL (R)) to microcrystalline tyrosine (MCT) in formulations for use in allergy immunotherapy

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The adsorption of allergoids and 3-O-desacyl-4 '-monophosphoryl lipid A (MPL (R)) to microcrystalline tyrosine (MCT) in formulations for use in allergy immunotherapy

机译：在变态反应免疫疗法中使用的变应性变体和3-O-去酰基-4'-单磷酰基脂质A（MPL（R））吸附到微晶酪氨酸（MCT）中

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Infectious disease vaccine potency is affected by antigen adjuvant adsorption. WHO and EMA guidelines recommend limits and experimental monitoring of adsorption in vaccines and allergy immunotherapies. Adsorbed allergoids and MPL (R) in MATA-MPL allergy immunotherapy formulations effectively treat IgE mitigated allergy. Understanding vaccine antigen adjuvant adsorption allows optimisation of potency and should be seen as good practice; however current understanding is seldom applied to allergy immunotherapies.

机译：传染性疾病疫苗效力受抗原佐剂吸附的影响。 WHO和EMA指南建议限制和实验监测疫苗和过敏免疫疗法中的吸附。 MATA-MPL过敏免疫疗法配方中吸附的变态反应蛋白和MPL（R）有效治疗IgE缓解的过敏。了解疫苗抗原佐剂的吸附可以优化药效，应被视为良好做法。然而，目前的认识很少应用于过敏免疫疗法。

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《Journal of Inorganic Biochemistry: An Interdisciplinary Journal》 |2015年第null期|共7页
作者
Bell A. J.; Heath M. D.; Hewings S. J.; Skinner M. A.;
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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
Adjuvant adsorption; Allergoid; Monophosphoryl lipid A; Microcrystalline tyrosine; Modified allergen tyrosine adsorbed; C-H center dot center dot center dot pi interactions;

机译：佐剂吸附;变应原;单磷酰脂质A;微晶酪氨酸;修饰的变应原酪氨酸吸附;C-H中心点中心点中心点pi相互作用;

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1. The adsorption of allergoids and 3-O-desacyl-4 '-monophosphoryl lipid A (MPL (R)) to microcrystalline tyrosine (MCT) in formulations for use in allergy immunotherapy [J] . Bell A. J., Heath M. D., Hewings S. J., Journal of Inorganic Biochemistry: An Interdisciplinary Journal . 2015,第Null期

机译：在变态反应免疫疗法中使用的变应性变体和3-O-去酰基-4'-单磷酰基脂质A（MPL（R））吸附到微晶酪氨酸（MCT）中
2. Microcrystalline Tyrosine (MCT ???? ): A Depot Adjuvant in Licensed Allergy Immunotherapy Offers New Opportunities in Malaria [J] . Matthew D. Heath, Martin F. Bachmann, Matthias F. Kramer, Vaccines . 2017,第4期

机译：微晶酪氨酸（MCT ????）：许可的过敏性免疫治疗中的库房佐剂为疟疾提供了新的机会
3. Microcrystalline Tyrosine (MCT ???? ): A Depot Adjuvant in Licensed Allergy Immunotherapy Offers New Opportunities in Malaria [J] . Matthew D. Heath, Martin F. Bachmann, Matthias F. Kramer, Vaccines . 2017,第4期

机译：微晶酪氨酸（MCT ????）：许可的过敏性免疫疗法中的库房佐剂为疟疾提供了新的机会
4. A meta‐analysis on allergen‐specific immunotherapy using MCT® (MicroCrystalline Tyrosine)‐adsorbed allergoids in pollen allergic patients suffering from allergic rhinoconjunctivitis [O] . Sven Becker, Petra Zieglmayer, Gabriela Canto, 2021

机译：患有MCT®（微晶酪氨酸）的过敏原特异性免疫疗法的荟萃分析Pollen过敏患者患有过敏性鼻咽炎的花粉过敏性患者
5. The adsorption of allergoids and 3-O-desacyl-4′-monophosphoryl lipid A (MPL®) to microcrystalline tyrosine (MCT) in formulations for use in allergy immunotherapy [O] . Bell A.J., Heath M.D., Hewings S.J., 2015

机译：用于过敏性免疫疗法的制剂中的变应性变体和3-O-去酰基-4'-单磷酰基脂质A（MPL®）吸附至微晶酪氨酸（MCT）

The adsorption of allergoids and 3-O-desacyl-4 '-monophosphoryl lipid A (MPL (R)) to microcrystalline tyrosine (MCT) in formulations for use in allergy immunotherapy

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