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首页> 外文期刊>Journal of Inorganic Biochemistry: An Interdisciplinary Journal >The (biological) speciation of vanadate(V) as revealed by V-51 NMR: A tribute on Lage Pettersson and his work
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The (biological) speciation of vanadate(V) as revealed by V-51 NMR: A tribute on Lage Pettersson and his work

机译：V-51 NMR揭示钒酸盐（V）的（生物）形态：对拉格·佩特森及其工作的敬意

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摘要

Four decades of research carried out by Lage Pettersson, his group and his coworkers are reviewed, research that has been directed predominantly towards the speciation of vanadate and systems containing, along with vanadate and co-reactants such as phosphate and peroxide, biologically relevant organics. In particular, those organics have been addressed that either are (potential) ligands for vanadate-derived coordination compounds generated at physiological conditions and/or function as constituents in medicinally interesting oxidovanadium compounds. Examples for molecules introduced in the context of the physiological vanadate-ligand interaction include the dipeptides Pro-Ala, Ala-Gly, Ala-His and Ala-Ser, the serum constituents lactate and citrate, and the nucleobases adenosine and uridine. The speciation in the vanadate-picolinate and vanadate-maltol systems is geared towards insulin-enhancing vanadium drugs. The speciation as a function of pH, ionic strength and the concentration of vanadate and the ligand(s) is based on potentiometric and V-51 NMR investigations, a methodical combination that allows reliable access to composition, formation constants and, to some extent, also structural details for the manifold of species present in aqueous media at physiological pH and beyond. The time frame 1971 to 2014 is reviewed, emphasizing the interval 1985 to 2006, and thus focusing on biologically interesting vanadium systems. Figurative representations from the original literature have been included. (C) 2015 Elsevier Inc. All rights reserved.
机译：回顾了拉格·佩特森（Lage Pettersson），他的小组和他的同事进行的四十年研究，该研究主要针对钒酸盐的形态，以及含有钒酸盐和共反应物（如磷酸盐和过氧化物）以及生物相关有机物的体系。特别地，已经解决了那些有机物，它们是在生理条件下产生的钒酸盐衍生的配位化合物的（潜在）配体和/或用作医学上感兴趣的氧化钒化合物的成分。在生理钒酸盐-配体相互作用的背景下引入的分子的实例包括二肽Pro-Ala，Ala-Gly，Ala-His和Ala-Ser，血清成分乳酸盐和柠檬酸盐以及核苷碱基腺苷和尿苷。钒-吡啶甲酸和钒-麦芽酚系统中的物种专门用于增强胰岛素的钒药物。 pH，离子强度以及钒酸盐和配体浓度的变化是基于电位和V-51 NMR研究的结果，这种方法学的组合可以可靠地获取组成，形成常数，并且在一定程度上还提供了生理pH或更高pH值下存在于水性介质中的各种物种的结构细节。回顾了1971年至2014年的时间框架，强调了1985年至2006年的时间间隔，因此侧重于生物学上有趣的钒系统。原始文献中的图形表示也已包括在内。 （C）2015 Elsevier Inc.保留所有权利。

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