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首页> 外文期刊>Journal of Inorganic Biochemistry: An Interdisciplinary Journal >Flavodiiron nitric oxide reductases: Recent developments in the mechanistic study and model chemistry for the catalytic reduction of NO
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Flavodiiron nitric oxide reductases: Recent developments in the mechanistic study and model chemistry for the catalytic reduction of NO

机译：Flavodiiron一氧化氮还原酶：催化还原NO的机理研究和模型化学的最新进展

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摘要

Inducible NO synthase in mammals helps to produce up to micromolar concentration of nitric oxide (NO) which acts as a key immune defense agent to kill invading pathogens. In order to counter the toxic effects of NO, the pathogens have expressed flavodiiron nitric oxide reductases (FNORs). The FNORs reduce the toxic NO into much less toxic N2O and thus help the pathogens to survive under nitrosative stress. As a consequence, these pathogens proliferate in the human body and cause harmful infections. An appreciable amount of research work has been performed to discover the true mechanism of the FNORs. Different mechanisms involving both mononitrosyl and dinitrosyl diiron complexes as key intermediates are proposed. Evidences for the involvement of new intermediates and more and more experimental evidences for existing ones in the proposed catalytic cycle of FNORs are coming up. These interesting biochemical events have recently boosted the biomimetic chemistry of the FNOR activity as well. This article discusses the importance and the currently understood mechanistic aspects of FNORs. Structural and functional models for the active site of FNORs are discussed along with their success and limitations. Possible future prospects of the modeling chemistry are also suggested. (C) 2014 Elsevier Inc. All rights reserved.
机译：哺乳动物中可诱导的一氧化氮合酶有助于产生高达微摩尔浓度的一氧化氮（NO），一氧化氮可作为杀死入侵病原体的关键免疫防御剂。为了抵消NO的毒性作用，病原体表达了Flavodiiron一氧化氮还原酶（FNORs）。 FNOR将有毒的NO还原为毒性较小的N2O，从而帮助病原体在亚硝化胁迫下生存。结果，这些病原体在人体内增殖并引起有害感染。已经进行了大量的研究工作，以发现FNOR的真正机理。提出了涉及单亚硝酰基和二亚硝酰基二铁配合物作为关键中间体的不同机理。新中间体参与的证据以及现有中间体在拟议的FNOR催化循环中的实验证据越来越多。这些有趣的生化事件最近也促进了FNOR活性的仿生化学。本文讨论FNOR的重要性和目前了解的机械方面。讨论了FNOR活动站点的结构和功能模型，以及它们的成功和局限性。还提出了建模化学的可能的未来前景。 （C）2014 Elsevier Inc.保留所有权利。

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