...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Inorganic Biochemistry: An Interdisciplinary Journal >Functional fluorescent nonporous silica nanoparticles as carriers for Pt(IV) anticancer prodrugs
【24h】

Functional fluorescent nonporous silica nanoparticles as carriers for Pt(IV) anticancer prodrugs

机译：功能性荧光无孔二氧化硅纳米粒子作为Pt（IV）抗癌前药的载体

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Multilayer fluorescent nonporous silica nanoparticles (SNPs) with an external shell containing primary amino groups were used as delivery systems for Pt(IV) candidate antitumor prodrugs. Spherical SNPs of three different sizes (diameter around 120, 100, and 50 nm) were loaded with two different complexes, namely (OC-6-33)-diamminebis(4-carboxybutanoato)dichloridoplatinum(IV) (1) and (OC-6-44)-diammine(4-carboxybutanoato) dichloridoethanolatoplatinum(IV) (2), through the formation of amide bonds between the pendant amino groups on SNPs and the free carboxylic groups of the complexes. Complex 1 proved to cause heavy and irreversible agglomeration of SNPs; likely, the presence of two reactive carboxylic functionalities induces the formation of cross-links between the amino-decorated SNPs. On the contrary, the conjugates 2-SNP, obtained from the monofunctionalized 2, afforded aqueous nano-suspensions reasonably stable toward aggregation. These solutions showed a limited Pt release in water in the absence of any reducing agents, mainly in form of a Pt(IV) derivative generated by the hydrolysis of the Si-O-Si bond of the functionalized arms attached to silica. In the presence of ascorbic acid, the reduction Pt(IV) -> Pt(II) caused the release of the active metabolite cisplatin. Conjugates 2-SNP exhibited much better antiproliferative activity on the Pt-sensitive ovarian A2780 cell line than parent cisplatin and free 2, due to their more efficient cellular uptake. (C) 2015 Elsevier Inc. All rights reserved.
机译：具有包含伯氨基的外壳的多层荧光无孔二氧化硅纳米粒子（SNP）被用作Pt（IV）候选抗肿瘤前药的递送系统。三种不同大小（直径分别为120、100和50 nm左右）的球形SNP上载有两种不同的复合物，即（OC-6-33）-二氨基双（4-羧基丁酸）二氯铂（IV）（1）和（OC-通过在SNP上的侧链氨基与配合物的游离羧基之间形成酰胺键，可以使2-（6-羧基）（4-羧基丁酸）二氯代乙醇合铂（IV）（2）。配合物1被证明会引起SNP大量且不可逆的聚集;很可能，两个反应性羧基官能团的存在会诱导氨基修饰的SNP之间形成交联。相反，从单官能化的2获得的缀合物2-SNP提供了对聚集相当稳定的水性纳米悬浮液。这些溶液在不存在任何还原剂的情况下显示出在水中有限的Pt释放，主要为通过附着在二氧化硅上的官能化臂的Si-O-Si键水解产生的Pt（IV）衍生物形式。在抗坏血酸的存在下，Pt（IV）→Pt（II）的还原导致活性代谢物顺铂的释放。结合物2-SNP对Pt敏感的卵巢A2780细胞系表现出比其母体顺铂和游离2更好的抗增殖活性，这是因为它们能更有效地吸收细胞。 （C）2015 Elsevier Inc.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号