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首页> 外文期刊>Journal of industrial and engineering chemistry >Visible light-induced photocurable (forming a film) low molecular weight chitosan derivatives for biomedical applications: Synthesis, characterization and in vitro biocompatibility
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Visible light-induced photocurable (forming a film) low molecular weight chitosan derivatives for biomedical applications: Synthesis, characterization and in vitro biocompatibility

机译:可见光诱导的可光固化(形成膜)的低分子量壳聚糖衍生物,用于生物医学应用:合成,表征和体外生物相容性

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In this work, visible light-induced photocurable low molecular weight chitosan derivatives (F-LMC: furfuryl-low molecular weight chitosan) were prepared by nitrous acid decomposition followed by modification with furfuryl glycidyl ether. The structure of the decomposition products (LMC: low molecular weight chitosan) was characterized by FT-IR analysis. The structure and molecular weight of F-LMC, prepared from the decomposition products by modification with furfuryl glycidyl ether, were characterized by ~1H NMR and GPC analysis, respectively. F-LMC was initially water-soluble, but after the exposure to visible light, it became water-insoluble, indicating that F-LMC undergoes visible light-induced inter- and intra-molecular cross-linking. The cross-linking was determined by concentration of F-LMC and time of exposure to visible light. The cytotoxicity test using fibroblast 3T3 showed no toxicity of F-LMC. Cross-linked F-LMC surface inhibited cell adherence.
机译:在这项工作中,通过亚硝酸分解,然后用糠基缩水甘油醚改性,制备了可见光诱导的可光固化的低分子量壳聚糖衍生物(F-LMC:糠基-低分子量壳聚糖)。通过FT-IR分析表征分解产物(LMC:低分子量壳聚糖)的结构。由糠醛缩水甘油醚改性后的分解产物制备的F-LMC的结构和分子量分别通过〜1H NMR和GPC分析进行表征。 F-LMC最初是水溶性的,但是在暴露于可见光之后,它变得不溶于水,这表明F-LMC经历了可见光诱导的分子间和分子内交联。通过F-LMC的浓度和暴露于可见光的时间确定交联。使用成纤维细胞3T3的细胞毒性试验显示F-LMC无毒性。交联的F-LMC表面抑制细胞粘附。

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