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首页> 外文期刊>Journal of industrial and engineering chemistry >Sequential optimization strategy for hyaluronic acid extraction from eggshell and its partial characterization
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Sequential optimization strategy for hyaluronic acid extraction from eggshell and its partial characterization

机译：从蛋壳中提取透明质酸的顺序优化策略及其部分表征

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摘要

The optimization of hyaluronic acid (HA) extraction from eggshell was studied by using a sequential experimentation approach. Using the results of factorial experiments, optimization experiments were carried out by response surface methodology. The experimental data as well as the validation tests showed the optimum performance when the extraction pH and time were bounded in the ranges of 3.4-3.5 and 3-3.4 days, respectively, at 9 °C.The purified HA was characterized by FTIR spectrum, harmonic mean size and average molecular weight. The study depicted the potential of eggshell as an alternative source for HA extraction to use in industry and medicine.
机译：采用顺序实验方法研究了从蛋壳中提取透明质酸的最优化方法。利用阶乘实验的结果，通过响应面方法进行了优化实验。实验数据和验证测试表明，在9°C下将萃取pH和时间分别限制在3.4-3.5天和3-3.4天范围内时，最佳性能是最佳的。谐波平均大小和平均分子量。该研究描述了蛋壳作为HA提取的替代来源在工业和医学中的潜力。

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