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首页> 外文期刊>Journal of industrial and engineering chemistry >Cell patterning on a poly(N-vinyl pyrrolidone)-patterned polystyrene substrate by using ion implantation
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Cell patterning on a poly(N-vinyl pyrrolidone)-patterned polystyrene substrate by using ion implantation

机译：通过离子注入在聚（N-乙烯基吡咯烷酮）图案的聚苯乙烯基板上进行图案化

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摘要

In this study, a simple strategy for micropatterning of cells was developed by using ion implantation that does not require any harsh chemicals and complicated processes. Thin poly(vinyl pyrrolidone) (PVP) films spin-coated on a nonbiological polystyrene Petri dishes were implanted with accelerated proton ions through a pattern mask and then developed with water to generate the patterns of the PVP. The results of the ATR-FTIR and XPS analysis revealed that the chemical compositions of the PVP were not significantly changed by ion implantation and thus the intrinsic biocompatibility of the PVP can be preserved. The in vitro cell culture on the patterned PVP showed selective alignment of cells on the PVP regions of the patterns and thus well-defined 100 μm patterns of the cells were obtained. These results revealed that this strategy is biocompatible and simple to use for biomolecular patterning, which can be used in further biological applications.
机译：在这项研究中，通过使用离子注入开发了一种简单的细胞微图案化策略，该离子注入不需要任何苛刻的化学药品和复杂的过程。旋涂在非生物聚苯乙烯陪替氏培养皿上的聚乙烯吡咯烷酮（PVP）薄膜很薄，通过图案掩模注入了加速的质子离子，然后用水显影以生成PVP的图案。 ATR-FTIR和XPS分析的结果表明，离子注入不会显着改变PVP的化学组成，因此可以保留PVP固有的生物相容性。在图案化的PVP上进行的体外细胞培养显示了图案的PVP区域上的细胞的选择性排列，因此获得了明确定义的100μm细胞图案。这些结果表明，该策略具有生物相容性，易于用于生物分子图案化，可用于进一步的生物学应用。

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