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首页> 外文期刊>Journal of industrial and engineering chemistry >Novel blend microspheres of cellulose triacetate and bee wax for the controlled release of nateglinide
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Novel blend microspheres of cellulose triacetate and bee wax for the controlled release of nateglinide

机译：三乙酸纤维素和蜂蜡的新型共混微球用于控制那格列奈的释放

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摘要

Blend microspheres of cellulose triacetate (CTA) and bee wax (BW) were prepared by oil-in-water (o/w) emulsion/solvent evaporation method for investigating the controlled release (CR) of nateglinide (NTG), an antidiabetic drug with a plasma half-life of 1.5 h. The novel carrier was analyzed for surface morphology, particle size, drug-polymer interactions, physical state of the encapsulated drug and micromeritic properties. In vitro release experiments were performed in simulated gastric (pH 1.2) and intestinal pH (7.4) media that was affected by blend composition and initial drug loading. In vitro release data were analyzed by empirical equations to understand the release profile of NTG
机译：通过水包油（o / w）乳剂/溶剂蒸发法制备三乙酸纤维素（CTA）和蜂蜡（BW）的共混微球，以研究那格列奈（NTG）的控释（CR）药物，该药物是血浆半衰期为1.5 h。分析了新型载体的表面形态，粒径，药物-聚合物相互作用，被包封药物的物理状态和微胶凝性能。体外释放实验是在受混合成分和初始载药量影响的模拟胃（pH 1.2）和肠pH（7.4）介质中进行的。通过经验方程分析体外释放数据，以了解NTG的释放曲线

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