Synthesis and evaluation of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl esters.

McComas CC; Crowley BM; Hwang I; Boger DL

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Synthesis and evaluation of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl esters.

机译：万古霉素，替考拉宁和瑞斯托汀糖苷配基甲基酯的甲基醚衍生物的合成和评价。

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摘要

A series of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl esters was synthesized and their antimicrobial activity was established. These derivatives exhibit increased activity against VanB resistant strains of bacteria equipotent with that observed with sensitive bacteria.

机译：合成了万古霉素，替考拉宁和瑞斯托汀糖苷配基甲基酯的一系列甲基醚衍生物，并确定了它们的抗菌活性。这些衍生物对与敏感细菌所观察到的细菌等效的VanB抗性菌株表现出增强的活性。

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来源
《Bioorganic and Medicinal Chemistry Letters》 |2003年第17期|共4页
作者
McComas CC; Crowley BM; Hwang I; Boger DL;
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正文语种 eng
中图分类基础医学;
关键词
derivatives; methyl ether; Vancomycin; Ristocetin; Esters; 万古霉素; 利托菌素; 酯类;

机译：derivatives;methyl ether;Vancomycin;Ristocetin;Esters;万古霉素;利托菌素;酯类;

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1. Synthesis and evaluation of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl esters. [J] . McComas CC, Crowley BM, Hwang I, Bioorganic and Medicinal Chemistry Letters . 2003,第17期

机译：万古霉素，替考拉宁和瑞斯托汀糖苷配基甲基酯的甲基醚衍生物的合成和评价。
2. Synthesis and biological evaluation of 6/7-exo-methyl-3beta-(4-iodo)phenyltropane-2beta-carboxylic acid methyl esters. [J] . Airaksinen AJ, Huotari M, Shvetsov A, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2005,第3期

机译：6 / 7-exo-methyl-3beta-（4-iodo）phenyltropane-2beta-羧酸甲酯的合成及生物学评估。
3. Total Syntheses and Initial Evaluation of [Ψ[C(=S)NH]Tpg~4]vancomycin,[Ψ[C(=NH)NH]Tpg~4]vancomycin, [Ψ[CH_2NH]Tpg~4]vancomycin, and Their (4-Chlorobiphenyl)methyl Derivatives: Synergistic Binding Pocket and Peripheral Modifications for the Glycopeptide Antibiotics [J] . Akinori Okano, Atsushi Nakayama, Kejia Wu, Journal of the American Chemical Society . 2015,第10期

机译：[Ψ[C（= S）NH] Tpg〜4]万古霉素，[Ψ[C（= NH）NH] Tpg〜4]万古霉素，[Ψ[CH [NH_2NH] Tpg〜4]万古霉素和他们的（4-氯苯基）甲基衍生物：糖肽抗生素的协同结合口袋和外围修饰。
4. Radiosynthesis and bio-evaluation of 123I-labelled 2-methyl-4-nitroimidazole derivatives as potential infection imaging agents [C] . D.D.Rossouw, M.G.L?tter, H.du Raan, Trends in Radiopharmaceuticals(ISTR-2005) . 2007

机译：123I标记的2-甲基-4-硝基咪唑衍生物作为潜在的感染显像剂的放射性合成和生物评价
5. Catalyst deactivation in the synthesis of methyl acetate from methyl ether using group VIII metal salts of phosphotungstic acid. [D] . Tartamella, Timothy Leonard. 1997

机译：使用磷钨酸的group族金属盐从甲醚合成乙酸甲酯时催化剂失活。
6. Synthesis and Evaluation of Selected Key Methyl Ether Derivatives of Vancomycin Aglycon [O] . Christine M. Crane, Joshua G. Pierce, Siegfried S. F. Leung, -1

机译：合成与选择的键甲基醚衍生物的评价万古霉素苷元
7. Synthesis and Evaluation of Selected Key Methyl Ether Derivatives of Vancomycin Aglycon [O] . Christine M. Crane, Joshua G. Pierce, Siegfried S. F. Leung, 2010

机译：Vancomycin aglycon选定关键甲基醚衍生物的合成与评价

Synthesis and evaluation of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl esters.

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