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首页> 外文期刊>Journal of industrial and engineering chemistry >Preparation and characterization of encapsulation of multiple lipid carrier (MLC) using vegetable fat
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Preparation and characterization of encapsulation of multiple lipid carrier (MLC) using vegetable fat

机译：植物脂肪包封多种脂质载体（MLC）的制备与表征

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The goal of this study is to establish the characterization of lipid carriers of a water-in-oil-in-water (W/O/ W) emulsion formation containing unstable hydrophilic active ingredients with an anti-wrinkle or whitening function, such as lipoic acid derivatives. In this experimental study, micrographs of multiple lipid carriers (MLCs) show that they are usually spherical, with a multiple emulsion droplet and multilamellar structure. It is shown that particle size and loading capacity are influenced by the concentration of hydrophilic or hydrophobic emulsifier, electrolyte content, and the type of thickening agent. The particle' diameter varied from about 27 μm to 361 μm, and the encapsulation efficiencies ranged from 18.3% to 80.7%. It was noted that particle' droplet breakdown was accelerated with the emulsifier content. The characterizations of MLC were dependent on the composition and choice of media. When the free methoxy PEG-45 thiocate was radiated using ultraviolet light (6.156 J/cm2), the residual content of methoxy PEG-45 thiocate rapidly decreased, but the residual content of methoxy PEG-45 thiocate encapsulated by MLC did not change much. Therefore, the lipid membrane of MLC act as a physical shielding membrane and leads to long-term storage stability in the drug, improving its photochemical stability against ultraviolet light.
机译：这项研究的目的是建立水包油包水（W / O / W）乳液形成中脂质载体的特性，该乳液包含不稳定的具有抗皱或增白功能的亲水性活性成分，例如硫辛酸酸衍生物。在这项实验研究中，多种脂质载体（MLC）的显微照片显示，它们通常是球形的，具有多个乳剂液滴和多层结构。结果表明，粒径和负载量受亲水或疏水乳化剂的浓度，电解质含量和增稠剂类型的影响。颗粒直径在约27μm至361μm之间变化，包封效率在18.3％至80.7％之间。注意到随着乳化剂含量的增加，颗粒的液滴破裂加速。 MLC的表征取决于培养基的组成和选择。当使用紫外线（6.156 J / cm2）辐射游离的甲氧基PEG-45硫醇盐时，甲氧基PEG-45硫醇盐的残留量迅速降低，但用MLC封装的甲氧基PEG-45硫醇盐的残留量变化不大。因此，MLC的脂质膜可充当物理屏蔽膜，并导致在药物中的长期存储稳定性，从而提高了其对紫外线的光化学稳定性。

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