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首页> 外文期刊>Journal of laparoendoscopic and advanced surgical techniques, Part A >Endoscopic submucosal dissection for rectal neuroendocrine (carcinoid) tumors.
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Endoscopic submucosal dissection for rectal neuroendocrine (carcinoid) tumors.

机译：内窥镜黏膜下剥离术治疗直肠神经内分泌（类癌）肿瘤。

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PURPOSE: Rectal neuroendocrine (carcinoid) tumors smaller than 1 cm without lymph node metastasis and confined within the submucosal layer (stage T1aN0) can be treated using endoscopic resection. The present study was aimed to assess the safety and efficacy of endoscopic submucosal dissection (ESD) for T1aN0 carcinoid tumors. PATIENTS AND METHODS: A total of 35 consecutive patients with a T1aN0 rectal carcinoid tumor were enrolled between March 2007 and December 2009. The study evaluated the histologically complete resection rate, procedure time, complications, and short-term oncological outcomes. RESULTS: The mean patient age was 49.0 years (range, 32-74 years), and there were 25 men and 10 women. The mean procedure time was 35.6 minutes (range, 7-82 minutes). All neoplasms were removed in one piece, and the histologically complete resection rate was 74.3% (26 cases including 5 cases showing no residual tumor). No post-ESD bleeding was observed. Abdominal computed tomography scans showed a perforation in 1 patient only, but that perforation was not associated with any peritonitis symptoms, and the patient was discharged on postprocedure day 3. One patient underwent radical surgery after ESD because of angiolymphatic invasion and positive resection margins, and the final pathology revealed no residual tumor or lymph node metastasis. No patient showed local recurrence or distant metastasis during a median follow-up of 25 months (range, 12-43 months). CONCLUSIONS: ESD is feasible and safe for treating T1aN0 rectal carcinoid tumors. Further studies are required to accurately determine long-term oncological outcomes.
机译：目的：直肠内分泌（类癌）小于1 cm的肿瘤，无淋巴结转移，并局限于粘膜下层（T1aN0期），可使用内镜切除术治疗。本研究旨在评估T1aN0类癌肿瘤的内镜黏膜下剥离术（ESD）的安全性和有效性。患者与方法：自2007年3月至2009年12月，共有35例T1aN0直肠类癌肿瘤患者入组。该研究评估了组织学上完整的切除率，手术时间，并发症和短期肿瘤学结局。结果：平均患者年龄为49.0岁（范围32-74岁），男性25例，女性10例。平均手术时间为35.6分钟（范围7-82分钟）。所有肿瘤被一并切除，组织学完全切除率为74.3％（26例，其中5例无残留肿瘤）。没有观察到ESD后出血。腹部计算机断层扫描仅显示1例穿孔，但该穿孔与任何腹膜炎症状均无关联，并且该患者在手术后第3天出院。由于血管淋巴管浸润和阳性切除切缘，一名患者在ESD后接受了根治性手术。最终病理显示无残留肿瘤或淋巴结转移。在25个月的中位随访期间（12-43个月），没有患者显示出局部复发或远处转移。结论：ESD治疗T1aN0直肠类癌是可行且安全的。需要进一步的研究以准确确定长期的肿瘤学结果。

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