Editorial: protein C and S deficiency as a risk factor for stent thrombosis--when a rare disorder can predispose to rare events.

Abdel Latif A; Moliterno DJ

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Editorial: protein C and S deficiency as a risk factor for stent thrombosis--when a rare disorder can predispose to rare events.

机译：社论：蛋白质C和S缺乏症是支架血栓形成的危险因素-罕见疾病可能导致罕见事件发生。

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The use of drug-eluting stents has significantly reduced the risk of restenosis and target vessel revas-cularization.1'2 However, with the delayed stent en-dothelialization, the risk of stent thrombosis (ST), a rare but high-morbidity and high-mortality event,3 has been documented in multiple reports. A number of clinical and procedural risk factors have been correlated with ST in clinical trials and practice, and include premature discontinuation of dual antiplatelet therapy, renal failure, bifurcation stenting, small vessel percutaneous coronary intervention (PCI), prior brachytherapy, suboptimal stent result, acute coronary syndrome, diabetes, complex lesions, and depressed left ventricular systolic function.

机译：药物洗脱支架的使用显着降低了再狭窄和靶血管再血管化的风险。1'2然而，由于支架的覆膜化延迟，支架血栓形成（ST）的风险，罕见但高发病率和高死亡率事件3已在多个报告中记录。在临床试验和实践中，许多临床和程序风险因素均与ST相关，包括过早停用双重抗血小板治疗，肾功能衰竭，分叉支架置入，小血管经皮冠状动脉介入治疗（PCI），先前的近距离放射治疗，支架效果欠佳，急性冠状动脉综合征，糖尿病，复杂病变和左心室收缩功能低下。

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《Journal of interventional cardiology》 |2010年第6期|共4页
作者
Abdel Latif A; Moliterno DJ;
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1. Editorial: protein C and S deficiency as a risk factor for stent thrombosis--when a rare disorder can predispose to rare events. [J] . Abdel Latif A, Moliterno DJ Journal of interventional cardiology . 2010,第6期

机译：社论：蛋白质C和S缺乏症是支架血栓形成的危险因素-罕见疾病可能导致罕见事件发生。
2. Rare Bleeding Disorder Registry: deficiencies of factors II, V, VII, X, XIII, fibrinogen and dysfibrinogenemias. [J] . Acharya SS, Coughlin A, Dimichele DM Journal of thrombosis and haemostasis: JTH . 2004,第2期

机译：罕见的出血性疾病注册表：缺乏因子II，V，VII，X，XIII，纤维蛋白原和血纤维蛋白原血症。
3. Clinical impact and predisposing factors of delayed-onset neutropenia after autologous hematopoietic stem-cell transplantation for B-cell non-Hodgkin lymphoma: association with an incremental risk of infectious events. [J] . Kato H, Yamamoto K, Matsuo K, Annals of oncology: official journal of the European Society for Medical Oncology . 2010,第8期

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Editorial: protein C and S deficiency as a risk factor for stent thrombosis--when a rare disorder can predispose to rare events.

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