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首页> 外文期刊>Journal of investigative medicine >Association between serum vitamin B12 levels and the degree of steatosis in patients with nonalcoholic Fatty liver disease.
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Association between serum vitamin B12 levels and the degree of steatosis in patients with nonalcoholic Fatty liver disease.

机译：非酒精性脂肪肝患者血清维生素B12水平与脂肪变性程度之间的关联。

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PURPOSE: : A relationship between liver diseases and serum vitamin B12 levels was observed in previous reports. The purpose of this study was to determine if a similar relationship existed between vitamin B12 and nonalcoholic fatty liver disease (NAFLD), a common chronic liver disorder. MATERIALS AND METHODS: : A total of 45 consecutive patients with NAFLD formed the NAFLD group, whereas 30 healthy controls (HC) formed the HC group. The subjects in all of the groups were of similar age and body mass index (BMI). A fatty liver is described in 3 ultrasonographic grades. Fasting blood samples were obtained, and serum vitamin B12 levels were measured. In addition, liver enzymes including aspartate aminotransferase, alanine aminotransferase (ALT), and alkaline phosphatase, and folic acid and other serum parameters were evaluated. The Mann-Whitney U test, chi test, and Spearman correlation analysis were used to compare the vitamin B12 levels and other serum parameters in both groups. RESULTS: : The mean +/- SD age and BMI of the NAFLD were 47.2 +/- 11.2 and 28.8 +/- 3.5. The mean +/- SD age and BMI of the HC were 47.1 +/- 8.8 and 27.7 +/- 2.9, respectively. The serum aspartate aminotransferase and ALT levels of the patients with NAFLD were statistically higher compared with those of the controls (P = 0.001). The levels of vitamin B12 and folate were statistically lower in the NAFLD patients compared with those of the controls (P < 0.05). We found that there was a reduction of vitamin B12 levels, especially in grade 2 to grade 3 hepatosteatosis. In addition, in the Spearman correlation analysis between the vitamin B12 levels and ALT, the grade of fatty liver and the liver dimension were found to have an important negative correlation. CONCLUSION: : The serum vitamin B12 levels were significantly lower in the patients with NAFLD than in those of the control group; however, these still remain in the reference range. Consequently, low vitamin B12 levels may be associated with NAFLD especially in grade 2 to grade 3 hepatosteatosis.
机译：目的：在先前的报告中观察到肝脏疾病与血清维生素B12水平之间的关系。这项研究的目的是确定维生素B12与非酒精性脂肪肝疾病（NAFLD）（一种常见的慢性肝病）之间是否存在相似的关系。材料与方法：总共45名连续的NAFLD患者组成了NAFLD组，而30名健康对照（HC）组成了HC组。所有组中的受试者年龄和体重指数（BMI）相似。脂肪肝分为3种超声检查等级。获得空腹血液样品，并测量血清维生素B12水平。此外，评估了包括天冬氨酸转氨酶，丙氨酸转氨酶（ALT）和碱性磷酸酶在内的肝酶，叶酸和其他血清参数。使用Mann-Whitney U检验，chi检验和Spearman相关分析来比较两组中的维生素B12水平和其他血清参数。结果：NAFLD的平均+/- SD年龄和BMI为47.2 +/- 11.2和28.8 +/- 3.5。 HC的平均+/- SD年龄和BMI分别为47.1 +/- 8.8和27.7 +/- 2.9。与对照组相比，NAFLD患者的血清天冬氨酸转氨酶和ALT水平在统计学上更高（P = 0.001）。与对照组相比，NAFLD患者的维生素B12和叶酸水平在统计学上较低（P <0.05）。我们发现维生素B12含量降低，尤其是从2级到3级肝脂肪变性。另外，在维生素B12水平和ALT之间的Spearman相关性分析中，发现脂肪肝的等级和肝脏的大小具有重要的负相关性。结论：NAFLD患者的血清维生素B12水平明显低于对照组。但是，这些仍然在参考范围内。因此，低维生素B12水平可能与NAFLD相关，尤其是在2至3级肝脂肪变性中。

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