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首页> 外文期刊>Journal of Internal Medicine >Gender difference of association between LDL cholesterol concentrations and mortality from coronary heart disease amongst Japanese: the Ibaraki Prefectural Health Study.
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Gender difference of association between LDL cholesterol concentrations and mortality from coronary heart disease amongst Japanese: the Ibaraki Prefectural Health Study.

机译：日本人中LDL胆固醇浓度与冠心病死亡率之间关联的性别差异：茨城县健康研究。

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OBJECTIVE: The aim of this study was to examine whether LDL cholesterol raises the risk of coronary heart disease in a dose-response fashion in a population with low LDL-cholesterol levels. DESIGN: Population-based prospective cohort study in Japan. SUBJECTS AND MAIN OUTCOME MEASURES: A total of 30,802 men and 60,417 women, aged 40 to 79 years with no history of stroke or coronary heart disease, completed a baseline risk factor survey in 1993. Systematic mortality surveillance was performed through 2003 and 539 coronary heart disease deaths were identified. RESULTS: The mean values for LDL-cholesterol were 110.5 mg dL(-1) (2.86 mmol L(-1)) for men and 123.9 mg dL(-1) (3.20 mmol L(-1)) for women. Men with LDL-cholesterol > or =140 mg dL(-1) (> or =3.62 mmol L(-1)) had two-fold higher age-adjusted risk of mortality from coronary heart disease than did those with LDL-cholesterol <80 mg dL(-1) (<2.06 mmol L(-1)), whereas no such association for women was found. The multivariable hazard ratio for the highest versus lowest categories of LDL-cholesterol was 2.06 (95 percent confidence interval: 1.34 to 3.17) for men and 1.16 (0.64 to 2.12) for women. CONCLUSION: Higher concentrations of LDL-cholesterol were associated with an increased risk of mortality from coronary heart disease for men, but not for women, in a low cholesterol population.
机译：目的：本研究的目的是研究低密度脂蛋白胆固醇水平低的人群中低密度脂蛋白胆固醇是否以剂量反应的方式增加冠心病的风险。设计：在日本进行的基于人口的前瞻性队列研究。受试者和主要观察指标：共有30,802名男性和60,417名女性，年龄在40至79岁之间，无中风或冠心病病史，并于1993年完成了基线危险因素调查。系统性死亡监测在2003年和539例中进行。确定了疾病死亡。结果：男性的LDL-胆固醇平均值为110.5 mg dL（-1）（2.86 mmol L（-1）），女性为123.9 mg dL（-1）（3.20 mmol L（-1））。 LDL-胆固醇>或= 140 mg dL（-1）（>或= 3.62 mmol L（-1））的男性经年龄调整后的冠心病死亡风险比LDL-胆固醇<2的男性高2倍。 80 mg dL（-1）（<2.06 mmol L（-1）），但未发现与女性有这种关联。 LDL-胆固醇最高和最低类别的多变量风险比为男性为2.06（95％置信区间：1.34至3.17），女性为1.16（0.64至2.12）。结论：在低胆固醇人群中，较高浓度的LDL-胆固醇与男性冠心病死亡风险增加有关，而与女性无关。

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