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首页> 外文期刊>Journal of Lipid Research >Neutral sterols of rat epididymis. High concentrations of dehydrocholesterols in rat caput epididymidis.
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Neutral sterols of rat epididymis. High concentrations of dehydrocholesterols in rat caput epididymidis.

机译：大鼠附睾中性固醇。大鼠附睾附睾中的高浓度脱氢胆固醇。

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摘要

Phospholipids and sterols are known to have multiple functions in reproductive tissue of mammals. High concentrations of the cholesterol precursor desmosterol have been described in testis, epididymis, and spermatozoa of various species. These findings and the recent discovery of some cholesterol precursors as meiosis-activating sterols suggest important functions of cholesterol precursors in fertility. Many sterol intermediates appear from the 19-step conversion of lanosterol, the first sterol synthesized in the cascade of cholesterol synthesis, to cholesterol. The biochemical basis of the genetically inherited Smith-Lemli-Opitz syndrome has been described as a defective conversion of 7-dehydrocholesterol to cholesterol. Since this discovery, interest has focused on this special cholesterol precursor. Here, we report high concentrations of 7- and 8-dehydrocholesterol in caput epididymidis and spermatozoa derived from caput epididymidis of Sprague-Dawley and Wistar rats, which comprised up to 30% of total sterols. In contrast to caput epididymidis, 7- and 8-dehydrocholesterol were barely detected in cauda epididymidis or testis. Desmosterol increased several times from caput to cauda epididymidis.This is the first report of the natural appearance of high concentrations of dehydrocholesterols in mammalian tissue, and it underlines the putative importance of cholesterol precursors in reproductive tissue.
机译：已知磷脂和固醇在哺乳动物的生殖组织中具有多种功能。已经在各种物种的睾丸，附睾和精子中描述了高浓度的胆固醇前体去甾醇。这些发现以及最近发现的一些胆固醇前体作为减数分裂激活固醇，表明胆固醇前体在生育中具有重要作用。羊毛甾醇的19步转化过程中出现了许多固醇中间体，羊毛甾醇是在胆固醇合成的级联反应中合成的首个固醇，转化为胆固醇。遗传上遗传的史密斯-莱姆利-奥皮兹综合征的生化基础已被描述为7-脱氢胆固醇向胆固醇的转化不良。自从发现以来，人们的兴趣就集中在这种特殊的胆固醇前体上。在这里，我们报道了Sprague-Dawley和Wistar大鼠的附睾附睾和附睾附睾和精子中的高浓度7-和8-脱氢胆固醇，占总固醇的30％。与附睾附睾相反，附睾或睾丸几乎没有检测到7-和8-脱氢胆固醇。去角质醇从附子到附睾毛刺增加了数倍。这是哺乳动物组织中高浓度脱氢胆固醇自然出现的第一个报道，它强调了胆固醇前体在生殖组织中的重要地位。

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