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首页> 外文期刊>Journal of Korean medical science >Gender differences in the association between depressive symptoms and carotid atherosclerosis among middle-aged and older Koreans: the Namwon study.
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Gender differences in the association between depressive symptoms and carotid atherosclerosis among middle-aged and older Koreans: the Namwon study.

机译：Namwon研究显示，中老年人和韩国人的抑郁症状与颈动脉粥样硬化之间的关联存在性别差异。

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摘要

We investigated the association of depressive symptoms with carotid intima-media thickness (IMT) and plaques in the general Korean population. A total of 7,554 Korean males and females aged 45-74 yr who were free from cardiovascular diseases were included in the analyses. Depressive symptoms were assessed by the Center for Epidemiologic Studies Depression Scale (CES-D). Subjects with a score of ≥16 were classified as having clinically significant depressive symptoms. Carotid ultrasonography was used to measure mean carotid IMT (C-IMT) and to determine the presence of plaques. A significant association between depressive symptoms and C-IMT was observed only in females. After adjustment for established cardiovascular risk factors, females with depressive symptoms had significantly greater C-IMT than females without depressive symptoms (mean difference 0.011±0.004 mm; 95% confidence interval, 0.003-0.019 mm). Compared with controls, the fully adjusted risk of females with depressive symptoms for abnormal C-IMT (≥1.0 mm) was significant (odds ratio, 1.63; 95% confidence interval, 1.16-2.30). No significant association between depressive symptoms and carotid plaques was observed in either gender. This study shows a significant association between depressive symptoms and C-IMT in middle-aged and older females.
机译：我们调查了韩国一般人群中抑郁症状与颈动脉内膜中层厚度（IMT）和斑块的关系。这项分析共纳入了7,554名年龄在45-74岁之间的韩国男性和女性，他们没有心血管疾病。抑郁症状由流行病学研究中心抑郁量表（CES-D）评估。得分≥16的受试者被分类为具有临床上显着的抑郁症状。颈动脉超声检查用于测量平均颈动脉IMT（C-IMT）并确定斑块的存在。仅在女性中观察到抑郁症状和C-IMT之间的显着关联。调整已确定的心血管危险因素后，具有抑郁症状的女性的C-IMT明显高于没有抑郁症状的女性（平均差异0.011±0.004 mm; 95％置信区间为0.003-0.019 mm）。与对照组相比，具有抑郁症状的女性完全调整后的C-IMT异常（≥1.0mm）风险显着（优势比为1.63; 95％置信区间为1.16-2.30）。两种性别均未观察到抑郁症状与颈动脉斑块之间的显着关联。这项研究表明，中老年女性的抑郁症状与C-IMT之间存在显着相关性。

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