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首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >Interferon-alpha as an immunotherapeutic protein.
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Interferon-alpha as an immunotherapeutic protein.

机译：干扰素-α作为免疫治疗蛋白。

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摘要

Interferon-alpha (IFN-alpha) has proven to be a clinically effective antiviral and antineoplastic therapeutic drug for more than 16 years. During this time, evidence from in vitro laboratory studies and the clinical arena has supported the concept that IFN-alpha is an immunotherapeutic drug. By regulating a diverse set of cytokines and their receptors, IFN-alpha is uniquely positioned to prime the host immune response and provide an effective antineoplastic- and antiviral-immune response. IFN-alpha stimulates the innate cell-mediated response and then participates in the transition of the initial host innate response into an effective adaptive-immune response. IFN-alpha also drives the adaptive cell-mediated CD8+ T-cell response and helps to maintain a CD4+ Th1-cell population balance for an effective antineoplastic and antiviral host defense. This review will describe the current state of knowledge of IFN-alpha as an immunoregulatory protein and address specific issues of IFN-alpha as an immunotherapeutic for antineoplastic and antiviral diseases.
机译：干扰素-α（IFN-α）已被证明是临床有效的抗病毒和抗肿瘤治疗药物已有16年以上的历史。在这段时间内，来自体外实验室研究和临床舞台的证据支持了IFN-α是一种免疫治疗药物的概念。通过调节多种细胞因子及其受体，IFN-α处于独特的位置，可以引发宿主免疫应答并提供有效的抗肿瘤和抗病毒免疫应答。 IFN-α刺激先天细胞介导的反应，然后参与初始宿主先天反应向有效适应性免疫反应的转变。 IFN-α还可以驱动适应性细胞介导的CD8 + T细胞反应，并有助于维持CD4 + Th1-细胞群体平衡，从而实现有效的抗肿瘤和抗病毒宿主防御。这篇综述将描述作为免疫调节蛋白的IFN-α的当前知识水平，并解决作为抗肿瘤和抗病毒疾病的免疫疗法的IFN-α的特定问题。

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