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首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >HMGB1 preconditioning: therapeutic application for a danger signal?
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HMGB1 preconditioning: therapeutic application for a danger signal?

机译：HMGB1预处理：危险信号的治疗应用？

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摘要

High mobility group box 1 (HMGB1) is a nuclear factor released extracellularly as a late mediator of lethality in sepsis and as an early mediator of inflammation following injury. In contrast to the proinflammatory role of HMGB1, recent evidence suggests beneficial applications of HMGB1 in injury states. One such application is the use of HMGB1 as a preconditioning stimulus. Preconditioning is a phenomenon whereby a low level of stressful stimuli confers protection against subsequent injury. Preconditioning has been demonstrated in multiple species, can be induced by various stimuli, and is applicable in different organ systems. Only with the recent introduction of the concept of endogenous molecules, such as HMGB1, as signals and mediators for inflammation during injury states has the use of endogenous molecules been investigated for this use. This review will focus on the use of endogenous molecules, specifically HMGB1, as a preconditioning stimulus and its mechanism of protection, as well as other protective applications for HMGB1.
机译：高迁移率族盒1（HMGB1）是一种细胞外释放的核因子，是脓毒症致死率的晚期介体和损伤后炎症的早期介体。与HMGB1的促炎作用相反，最新证据表明HMGB1在损伤状态中有有益的应用。一种这样的应用是将HMGB1用作预处理刺激。预处理是一种现象，在这种情况下，低水平的压力刺激可防止后续伤害。预处理已经在多种物种中得到证明，可以通过各种刺激来诱导，并且适用于不同的器官系统。仅在最近引入内源性分子（例如HMGB1）作为损伤状态期间炎症的信号和介质的概念时，才对内源性分子的用途进行了研究。本文将重点研究内源性分子，特别是HMGB1，作为预处理刺激及其保护机制，以及对HMGB1的其他保护应用。

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