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首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >A case for immunization against nosocomial infections.
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A case for immunization against nosocomial infections.

机译：一例针对医院感染的免疫接种。

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摘要

Immunization is a highly effective public health measure that reduces the incidence of infectious diseases, yet there has been relatively little effort toward the development of vaccines for nosocomial infections. Many nosocomial infections originate on mucosal surfaces (e.g., respiratory or gastrointestinal mucosa). As patients who are hospitalized once are more likely to be hospitalized again, we propose a prime-boost immunization strategy, whereby a priming dose of vaccine for a nosocomial infection is administered mucosally. Upon readmission, a parenteral boost would elicit a rapid immune response locally and systemically. Such a strategy could reduce or ameliorate nosocomial infections and perhaps limit dissemination of nosocomial pathogens. Thus, a more aggressive effort to develop vaccines for nosocomial infections is warranted.
机译：免疫是一种有效的公共卫生措施，可降低传染病的发生率，但是，针对医院感染的疫苗研发工作却相对较少。许多医院感染起源于粘膜表面（例如呼吸道或胃肠道粘膜）。由于曾经住院的患者更有可能再次住院，因此我们提出了初免-加强免疫策略，即通过粘膜给予初次剂量的医院感染疫苗。重新入院后，肠胃外加强免疫将引起局部和全身快速的免疫反应。这种策略可以减少或改善医院感染，并可能限制医院病原体的传播。因此，需要更加积极的努力来开发用于医院感染的疫苗。

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