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首页> 外文期刊>Journal of Korean medical science >Bronchial anthracofibrosis and macroscopic tissue pigmentation on EBUS-TBNA predict a low probability of metastatic lymphadenopathy in Korean lung cancer patients
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Bronchial anthracofibrosis and macroscopic tissue pigmentation on EBUS-TBNA predict a low probability of metastatic lymphadenopathy in Korean lung cancer patients

机译：EBUS-TBNA上的支气管炭疽纤维化和宏观组织色素沉着预测韩国肺癌患者转移性淋巴结病的可能性低

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摘要

The identification of mediastinal lymph nodes (LNs) in lung cancer is an important step of treatment decision and prognosis prediction. The endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is widely used to assess the mediastinal LNs and tissue confirmation in lung cancer. As use of bronchoscopy or EBUS-TBNA has been increased, bronchial anthracofibrosis (BAF) has been detected frequently. Moreover, BAF is often accompanied by mediastinal lymphadenopathy and showed false-positive positron emission tomography uptake, which mimics metastatic lymphadenopathy in lung cancer patients. However, clinical implication of BAF during bronchoscopy is not well understood in lung cancer. We retrospectively reviewed 536 lungcancer patients who performed EBUS-TBNA and observed BAF in 55 patients. A total of 790 LNs were analyzed and macroscopic tissue pigmentation was observed in 228 patients. The adjusted odds ratio for predicting malignant LN was 0.46 for BAF, and 0.22 for macroscopic tissue pigmentation. The specificity of BAF and macroscopic tissue pigmentation for predicting a malignant LNwas 75.7% and 42.2%, respectively, which was higher than the specificity of using LN size or standard uptake value on PET. In conclusion, BAF and macroscopic tissue pigmentation during EBUS-TBNA are less commonly found in malignant LNs than reactive LNs in Korean lung cancer patients.
机译：肺癌纵隔淋巴结（LNs）的识别是治疗决策和预后预测的重要步骤。支气管内超声引导的经支气管针抽吸术（EBUS-TBNA）被广泛用于评估肺癌的纵隔LN和组织确诊。随着支气管镜检查或EBUS-TBNA的使用增加，经常检测到支气管纤维化（BAF）。此外，BAF经常伴有纵隔淋巴结肿大，并显示假阳性的正电子发射断层显像摄取，其可模拟肺癌患者的转移性淋巴结肿大。然而，在肺癌中，BAF在支气管镜检查中的临床意义尚不清楚。我们回顾性回顾了536例行EBUS-TBNA的肺癌患者，并观察了55例患者的BAF。分析了总共790个LN，并在228例患者中观察到宏观组织色素沉着。对于BAF，预测恶性LN的调整比值比为0.46，对于宏观组织色素沉着为0.22。 BAF和宏观组织色素沉着预测恶性LN的特异性分别为75.7％和42.2％，高于在PET上使用LN大小或标准摄取值的特异性。总之，在恶性LN中，EBUS-TBNA期间的BAF和肉眼可见的组织色素沉着在韩国肺癌患者中比反应性LN少见。

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