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首页> 外文期刊>Journal of Korean medical science >Influence of transforming growth factor-beta1 gene polymorphism at codon 10 on the development of cirrhosis in chronic hepatitis B virus carriers.
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Influence of transforming growth factor-beta1 gene polymorphism at codon 10 on the development of cirrhosis in chronic hepatitis B virus carriers.

机译：第10位密码子的转化生长因子β1基因多态性对慢性乙型肝炎病毒携带者肝硬化发展的影响。

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摘要

Transforming growth factor (TGF)-beta1 is a key cytokine producing extracellular matrix. We evaluated the effect of TGF-beta1 gene polymorphism at codon 10 on the development of cirrhosis in patients with chronic hepatitis B. One hundred seventy eight patients with chronic hepatitis (CH, n=57) or liver cirrhosis (LC, n=121), who had HBsAg and were over 50 yr old, were enrolled. The genotypes were determined by single strand conformation polymorphism. There were no significant differences in age and sex ratio between CH and LC groups. HBeAg positivity and detection rate of HBV DNA were higher in LC than in CH groups (P=0.055 and P=0.003, respectively). There were three types of TGF-beta1 gene polymorphism at codon 10: proline homozygous (P/P), proline/leucine heterozygous (P/L), and leucine homozygous (L/L) genotype. In CH group, the proportions of P/P, P/L, and L/L genotype were 32%, 51%, and 17%, respectively. In LC group, the proportions of those genotypes were 20%, 47%, and 33%, respectively. The L/L genotype was presented more frequently in LC than in CH groups (P=0.017). Multivariate logistic regression analysis confirms that detectable HBV DNA (odds ratio [OR]: 3.037, 95% confidence interval [CI]: 1.504-6.133, P=0.002) and L/L genotype (OR: 3.408, 95% CI: 1.279-9.085, P=0.014) are risk factors for cirrhosis.
机译：转化生长因子（TGF）-beta1是关键的细胞因子产生细胞外基质。我们评估了10位密码子的TGF-β1基因多态性对慢性乙型肝炎患者肝硬化发展的影响。178例慢性肝炎（CH，n = 57）或肝硬化（LC，n = 121）患者已入选HBsAg，年龄超过50岁的人。基因型通过单链构象多态性确定。 CH和LC组之间的年龄和性别比无显着差异。 LC组的HBeAg阳性率和HBV DNA检出率高于CH组（分别为P = 0.055和P = 0.003）。 TGF-beta1基因在10号密码子处有3种多态性：脯氨酸纯合（P / P），脯氨酸/亮氨酸杂合（P / L）和亮氨酸纯合（L / L）基因型。在CH组中，P / P，P / L和L / L基因型的比例分别为32％，51％和17％。在LC组中，这些基因型的比例分别为20％，47％和33％。与CH组相比，LC中L / L基因型的出现频率更高（P = 0.017）。多元逻辑回归分析确认可检测的HBV DNA（比值比[OR]：3.037，95％置信区间[CI]：1.504-6.133，P = 0.002）和L / L基因型（OR：3.408，95％CI：1.279- 9.085，P = 0.014）是肝硬化的危险因素。

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