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首页> 外文期刊>Journal of Korean medical science >Metabolic syndrome, insulin resistance and systemic inflammation as risk factors for reduced lung function in korean nonsmoking males.
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Metabolic syndrome, insulin resistance and systemic inflammation as risk factors for reduced lung function in korean nonsmoking males.

机译：代谢综合征，胰岛素抵抗和全身性炎症是韩裔非吸烟男性肺功能下降的危险因素。

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The aim of this study was done to assess the association of lung function with insulin resistance (IR), systemic inflammation, and metabolic syndrome (MetS). In 9,581 apparently healthy non-smoking male adults, pulmonary function, fasting glucose, insulin, lipid profiles and serum high-sensitivity C-reactive protein (hs-CRP) levels were measured, and homeostatic model assessment (HOMA) was used to assess IR. The presence of MetS was defined according to the AHA/NHLBI criteria. The prevalence of MetS was 19.3%. The odds ratio of MetS for restrictive ventilatory pattern was 1.55 (95% confidence interval, 1.12-2.14), and that for obstructive ventilatory pattern was 1.39 (0.66-2.94) after adjustment for confounders. When subjects were divided in 4 groups according to quartiles of FVC or FEV(1) (% predicted [pred]), HOMA-IR significantly increased as the FVC or FEV(1) (% predicted [pred]) decreased. Individuals in the lowest FVC or FEV(1) quartile had the highest hs-CRP level. Prevalence of MetS increased as FVC or FEV(1) (% predicted [pred]) quartiles decreased. The abdominal obesity, hs-CRP and HOMA-IR were the independent predictors for the lowest FVC and FEV(1) (% predicted [pred]) even after adjustment for confounders. These results indicate that MetS, IR, and systemic inflammation are important risk factors for reduced lung function in nonsmoking Korean males.
机译：这项研究的目的是评估肺功能与胰岛素抵抗（IR），全身性炎症和代谢综合征（MetS）的关联。在9,581名显然健康的非吸烟男性成年人中，测量了肺功能，空腹血糖，胰岛素，脂质谱和血清高敏C反应蛋白（hs-CRP）水平，并使用了稳态模型评估（HOMA）评估IR 。根据AHA / NHLBI标准定义MetS的存在。 MetS的患病率为19.3％。调整混杂因素后，限制性通气模式的MetS优势比为1.55（95％置信区间为1.12-2.14），阻塞性通气模式的MetS优势比为1.39（0.66-2.94）。当根据FVC或FEV（1）（预测的百分比[pred]）的四分位数将受试者分为4组时，HOMA-IR随着FVC或FEV（1）（预测的百分比[pred]）的降低而显着增加。 FVC或FEV（1）最低的四分之一中的hs-CRP水平最高。随着FVC或FEV（1）（预测的[pred]％）四分位数减少，MetS的患病率增加。即使校正了混杂因素，腹部肥胖，hs-CRP和HOMA-IR仍是最低FVC和FEV（1）（预测的百分比[pred]）的独立预测因子。这些结果表明，在不吸烟的韩国男性中，MetS，IR和全身性炎症是降低肺功能的重要危险因素。

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