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首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >Distinct and overlapping roles of CXCR5 and CCR7 in B-1 cell homing and early immunity against bacterial pathogens.
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Distinct and overlapping roles of CXCR5 and CCR7 in B-1 cell homing and early immunity against bacterial pathogens.

机译：CXCR5和CCR7在B-1细胞归巢和针对细菌病原体的早期免疫中的作用不同且重叠。

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摘要

CXC chemokine receptor (CXCR)5 and CC chemokine receptor (CCR)7 are the major chemokine receptors required for B cell homing and microenvironmental localization during antigen-independent and -dependent B cell differentiation. Here, we show markedly decreased B-1 B cell numbers in the peritoneal cavity of CXCR5-/- and CXCR5-/-CCR7-/- double-deficient mice paralleled by reduced antigen-induced phosphorylcholine-specific immunoglobulin (Ig)M responses after intraperitoneal (i.p.) administration of streptococcal antigen. CCR7-/- mice also revealed a partial reduction in peritoneal B-1 cell numbers combined with a reduced humoral response to i.p. injected bacterial antigen. However, opposite roles of CXCR5 and CCR7 were observed when the frequency of peritoneal B-2 cells was analyzed. CXCR5-/- mice almost completely lacked B-2 cells, whereas CCR7 deficiency engendered an increase in peritoneal B-2 cells. In addition, CCR7-/- mice had enhanced, splenic IgM+ plasma cell responses, whereas the extrafollicularB cell response of the CXCR5-/- mice was not significantly altered compared with wild-type controls. Thus, the two chemokine receptors exert divergent forces at multiple levels of the innate immune response. CXCR5 plays a dominant role in peritoneal B-1 B cell homing and body cavity immunity, but both chemokine receptors are needed for a proportional peritoneal B-2 cell homing and balanced development of an early splenic B cell response.
机译：CXC趋化因子受体（CXCR）5和CC趋化因子受体（CCR）7是抗原非依赖性和依赖性B细胞分化过程中B细胞归巢和微环境定位所需的主要趋化因子受体。在这里，我们显示CXCR5-/-和CXCR5-/-CCR7-/-双缺陷小鼠腹膜腔中的B-1 B细胞数量显着减少，同时经减少后的抗原诱导的磷酸胆碱特异性免疫球蛋白（Ig）M反应降低腹膜内（ip）施用链球菌抗原。 CCR7-/-小鼠还显示出腹膜B-1细胞数量的部分减少以及对i.p.的体液反应减少。注射细菌抗原。然而，当分析腹膜B-2细胞的频率时，观察到了CXCR5和CCR7的相反作用。 CXCR5-/-小鼠几乎完全缺乏B-2细胞，而CCR7缺乏引起腹膜B-2细胞增加。此外，CCR7-/-小鼠脾脏IgM +浆细胞反应增强，而与野生型对照相比，CXCR5-/-小鼠的滤泡外B细胞反应没有明显改变。因此，两个趋化因子受体在多种先天免疫应答水平上施加发散力。 CXCR5在腹膜B-1 B细胞归巢和体腔免疫中起着主导作用，但是，成比例的腹膜B-2细胞归巢和早期脾B细胞应答的均衡发展都需要两个趋化因子受体。

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