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首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >CD4(+)/CD8(+) double-positive T cells: more than just a developmental stage?
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CD4(+)/CD8(+) double-positive T cells: more than just a developmental stage?

机译：CD4（+）/ CD8（+）双阳性T细胞：不仅仅是发展阶段？

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摘要

CD4(+)/CD8(+) DP thymocytes are a well-described T cell developmental stage within the thymus. However, once differentiated, the CD4(+) lineage or the CD8(+) lineage is generally considered to be fixed. Nevertheless, mature CD4(+)/CD8(+) DP T cells have been described in the blood and peripheral lymphoid tissues of numerous species, as well as in numerous disease settings, including cancer. The expression of CD4 and CD8 is regulated by a very strict transcriptional program involving the transcription factors Runx3 and ThPOK. Initially thought to be mutually exclusive within CD4(+) and CD8(+) T cells, CD4(+)/CD8(+) T cell populations, outside of the thymus, have recently been described to express concurrently ThPOK and Runx3. Considerable heterogeneity exists within the CD4(+)/CD8(+) DP T cell pool, and the function of CD4(+)/CD8(+) T cell populations remains controversial, with conflicting reports describing cytotoxic or suppressive roles for these cells. In this review, we describe how transcriptional regulation, lineage of origin, heterogeneity of CD4 and CD8 expression, age, species, and specific disease settings influence the functionality of this rarely studied T cell population.
机译：CD4（+）/ CD8（+）DP胸腺细胞是胸腺内T细胞发育阶段的良好描述。但是，一旦区分，通常认为CD4（+）谱系或CD8（+）谱系是固定的。然而，已经在许多物种的血液和外周淋巴组织以及包括癌症在内的许多疾病中描述了成熟的CD4（+）/ CD8（+）DP T细胞。 CD4和CD8的表达受涉及转录因子Runx3和ThPOK的非常严格的转录程序调控。最初被认为在CD4（+）和CD8（+）T细胞内是相互排斥的，但最近已经描述了在胸腺之外的CD4（+）/ CD8（+）T细胞群体同时表达ThPOK和Runx3。 CD4（+）/ CD8（+）DP T细胞池中存在相当大的异质性，并且CD4（+）/ CD8（+）T细胞群的功能仍然存在争议，有关这些细胞具有细胞毒性或抑制作用的报道相互矛盾。在这篇综述中，我们描述了转录调控，起源谱系，CD4和CD8表达的异质性，年龄，物种和特定疾病背景如何影响这一鲜为研究的T细胞群体的功能。

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