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首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >Decidual natural killer cell receptor expression is altered in pregnancies with impaired vascular remodeling and a higher risk of pre-eclampsia
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Decidual natural killer cell receptor expression is altered in pregnancies with impaired vascular remodeling and a higher risk of pre-eclampsia

机译：妊娠中蜕膜性自然杀伤细胞受体表达改变，血管重构受损，先兆子痫风险增加

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摘要

During pregnancy, a specialized type of NK cell accumulates in the lining of the uterus (decidua) and interacts with semiallogeneic fetal trophoblast cells. dNK cells are functionally and phenotypically distinct from PB NK and are implicated in regulation of trophoblast transformation of the uterine spiral arteries, which if inadequately performed, can result in pregnancy disorders. Here, we have used uterine artery Doppler RI in the first trimester of pregnancy as a proxy measure of the extent of transformation of the spiral arteries to identify pregnancies with a high RI, indicative of impaired spiral artery remodeling. We have used flow cytometry to examine dNK cells isolated from these pregnancies compared with those from pregnancies with a normal RI. We report a reduction in the proportion of dNK cells from high RI pregnancies expressing KIR2DL/S1,3,5 and LILRB1, receptors for HLA-C and HLA-G on trophoblast. Decreased LILRB1 expression in the decidua was examined by receptor blocking in trophoblast coculture and altered dNK expression of the cytokines CXCL10 and TNF-alpha, which regulate trophoblast behavior. These results indicate that dNK cells from high RI pregnancies may display altered interactions with trophoblast via decreased expression of HLA-binding cell-surface receptors, impacting on successful transformation of the uterus for pregnancy.
机译：在怀孕期间，一种特殊类型的NK细胞积聚在子宫（蜕膜）中，并与半同种异体胎儿滋养层细胞相互作用。 dNK细胞在功能上和表型上与PB NK不同，并且与子宫螺旋动脉的滋养层转化有关，如果执行不当，可能会导致妊娠障碍。在这里，我们已使用妊娠前三个月的子宫动脉多普勒RI作为螺旋动脉转化程度的替代指标，以识别高RI的妊娠，这表明螺旋动脉重构受损。我们已经使用流式细胞术检查了从这些怀孕中分离的dNK细胞与正常RI怀孕中分离的dNK细胞。我们报告了从高RI妊娠表达滋养层细胞上的HLA-C和HLA-G受体KIR2DL / S1,3,5和LILRB1的dNK细胞比例减少。蜕膜中LILRB1表达的降低是通过滋养层共培养中的受体阻滞和改变调节滋养层行为的细胞因子CXCL10和TNF-α的dNK表达来检测的。这些结果表明，来自高RI妊娠的dNK细胞可能通过减少HLA结合细胞表面受体的表达而显示出与滋养层细胞相互作用的改变，从而影响妊娠子宫的成功转化。

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