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首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >The role of EMMPRIN in T cell biology and immunological diseases
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The role of EMMPRIN in T cell biology and immunological diseases

机译：EMMPRIN在T细胞生物学和免疫疾病中的作用

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摘要

EMMPRIN (CD147), originally described as an inducer of the expression of MMPs, has gained attention in its involvement in various immunologic diseases, such that anti-EMMPRIN antibodies are considered as potential therapeutic medications. Given that MMPs are involved in the pathogenesis of various disease states, it is relevant that targeting an upstream inducer would make for an effective therapeutic strategy. Additionally, EMMPRIN is now appreciated to have multiple roles apart from MMP induction, including in cellular functions, such as migration, adhesion, invasion, energy metabolism, as well as T cell activation and proliferation. Here, we review what is known about EMMPRIN in numerous immunologic/inflammatory disease conditions with a particular focus on its complex roles in T cell biology.
机译：最初被描述为MMPs表达的诱导剂的EMMPRIN（CD147）在涉及各种免疫疾病方面已引起关注，因此抗EMMPRIN抗体被认为是潜在的治疗药物。鉴于MMPs参与了各种疾病状态的发病机制，因此以上游诱导剂为靶点将有助于制定有效的治疗策略。另外，现在人们认识到EMMPRIN除了具有MMP诱导作用以外，还具有多种作用，包括在细胞功能中，例如迁移，粘附，侵袭，能量代谢以及T细胞活化和增殖。在这里，我们回顾了有关EMMPRIN在多种免疫/炎性疾病中的已知信息，特别关注了其在T细胞生物学中的复杂作用。

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