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首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >Sialyl lewisx antigen-expressing human CD4+ T and CD8+ T cells as initial immune responders in memory phenotype subsets.
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Sialyl lewisx antigen-expressing human CD4+ T and CD8+ T cells as initial immune responders in memory phenotype subsets.

机译：表达唾液酸化刘易士抗原的人CD4 + T和CD8 + T细胞是记忆表型亚群中的初始免疫应答。

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摘要

Cytokine production by memory T cells in secondary immune responses has a critical role in host defenses. Previously, we had demonstrated that a unique antigen composed of sialyl lewis(x) (sLe(x)) was expressed on CD45RO(+) memory-phenotype subsets of human T cells. Here, we found that the sLe(x) antigen was up-regulated on CD45RA(+) naive human CD4(+) T and CD8(+) T cells by TCR stimulation. In addition, sLe(x) antigen-expressing CD4(+) T and CD8(+) T cells in human PBMCs were activated immediately by cytokine stimulations composed of IL-2 plus IL-12 or IL-15 in an antigen-independent manner. Moreover, the sLe(x)-positive human CD8(+) T cells significantly enhanced reverse antibody-dependent cellular cytotoxicity compared with a sLe(x)-negative population. These findings clearly indicate that sLe(x) antigen-expressing memory phenotype CD4(+) T and CD8(+) T cells contribute to early-stage immunity by providing a source of IFN-gamma and cytotoxicity, suggesting that they would be a key immunomodulator in host defenses.
机译：记忆T细胞在次级免疫反应中产生的细胞因子在宿主防御中起关键作用。以前，我们已经证明了由唾液酸路易斯（x）（sLe（x））组成的独特抗原在人T细胞的CD45RO（+）记忆表型亚群上表达。在这里，我们发现通过TCR刺激，sLe（x）抗原在CD45RA（+）天真人CD4（+）T和CD8（+）T细胞上被上调。此外，人PBMC中表达sLe（x）抗原的CD4（+）T和CD8（+）T细胞被IL-2加IL-12或IL-15组成的细胞因子刺激以抗原独立的方式立即被激活。 。此外，与sLe（x）阴性人群相比，sLe（x）阳性人CD8（+）T细胞显着增强了反向抗体依赖性细胞的细胞毒性。这些发现清楚地表明，表达sLe（x）抗原的记忆表型CD4（+）T和CD8（+）T细胞通过提供IFN-γ和细胞毒性的来源而有助于早期免疫，这表明它们将是关键宿主防御中的免疫调节剂。

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