...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >Gender dimorphism following injury: making the connection from bench to bedside.
【24h】

Gender dimorphism following injury: making the connection from bench to bedside.

机译：受伤后的性别双态：从长凳到床头的连接。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Despite ongoing prevention efforts, injury remains the leading cause of mortality over the first three decades of life in the United States. Those who survive their initial injury continue to be plagued with the development of sepsis and multiple organ failure and their attributable morbidity and mortality. An important and persistent finding has been that males and females respond differently following traumatic injury and hemorrhagic shock. A significant advancement in the experimental understanding of the gender dimorphism in response to trauma-hemorrhage and sepsis has occurred. Experimental evidence for the differential effects of sex hormones on cell-mediated immunity and organ system tolerance of shock continues to expand. Clinical studies, however, have been unable to reproduce these laboratory bench findings consistently. There continues to be a divide between the "bench and bedside" in regard to our understanding of gender-based differences following injury. Relative to controlled animal experiments, predisposing comorbidities, injury characteristics, and a lack of information about the hormone milieu of the trauma patient disallow reproducible results from clinical analyses. Continued clinical research into potential sex hormone-based differences, genetic differences, and the cellular and molecular mechanisms responsible for these gender-based differential responses is required to close this gap. This may ultimately promote therapeutic interventions, which will allow for improved outcomes for males and females in the near future.
机译：尽管正在进行持续的预防工作，伤害仍然是美国生命头三十年中死亡的主要原因。那些在最初受伤后幸存下来的人继续遭受败血症和多器官衰竭的发展及其可归因的发病率和死亡率困扰。一个重要而持久的发现是，男性和女性在外伤和失血性休克后的反应不同。在对创伤，出血和脓毒症的反应中对性别二态性的实验理解方面取得了重大进展。性激素对细胞介导的免疫力和休克器官系统耐受性的不同作用的实验证据不断扩大。但是，临床研究无法始终如一地再现这些实验室工作台的发现。关于我们对受伤后基于性别的差异的理解，“长椅和床头”之间仍然存在分歧。相对于受控动物实验，易感性合并症，损伤特征以及有关创伤患者激素环境的信息缺乏，无法通过临床分析得出可重复的结果。为了弥合这一差距，需要对潜在的基于性激素的差异，遗传差异以及造成这些基于性别的差异反应的细胞和分子机制进行持续的临床研究。这最终可能会促进治疗干预，这将在不久的将来改善男性和女性的治疗效果。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号