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首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >The mononuclear phagocyte system revisited.
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The mononuclear phagocyte system revisited.

机译：重新检查了单核吞噬细胞系统。

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The mononuclear phagocyte system (MPS) was defined as a family of cells comprising bone marrow progenitors, blood monocytes, and tissue macrophages. In this review, we briefly consider markers for cells of this lineage in the mouse, especially the F4/80 surface antigen and the receptor for macrophage colony-stimulating factor. The concept of the MPS is challenged by evidence that there is a separate embryonic phagocyte lineage, the blurring of the boundaries between macrophages and other cells types arising from phenotypic plasticity and transdifferentiation, and evidence of local renewal of tissue macrophage populations as opposed to monocyte recruitment. Nevertheless, there is a unity to cells of the MPS suggested by their location, morphology, and shared markers. We discuss the origins of macrophage heterogeneity and argue that macrophages and antigen-representing dendritic cells are closely related and part of the MPS.
机译：单核吞噬细胞系统（MPS）被定义为包括骨髓祖细胞，血液单核细胞和组织巨噬细胞的细胞家族。在这篇综述中，我们简要地考虑了小鼠中该谱系细胞的标志物，尤其是F4 / 80表面抗原和巨噬细胞集落刺激因子的受体。 MPS的概念受到以下证据的挑战：证据是存在单独的胚胎吞噬细胞谱系，表型可塑性和转分化引起的巨噬细胞和其他细胞类型之间的边界模糊以及组织巨噬细胞群体发生局部更新而不是单核细胞募集的证据。尽管如此，MPS的位置，形态和共享标记暗示着它们的统一性。我们讨论了巨噬细胞异质性的起源，并认为巨噬细胞和代表抗原的树突状细胞密切相关，是MPS的一部分。

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