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首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages.
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Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages.

机译：FIZZ1和Ym1在交替激活与经典激活的巨噬细胞中的差异表达。

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摘要

Alternatively activated macrophages (aaMphi) display molecular and biological characteristics that differ from those of classically activated macrophages (caMphi). Recently, we described an experimental model of murine trypanosomosis in which the early stage of infection of mice with a Trypanosoma brucei brucei variant is characterized by the development of caMphi, whereas in the late and chronic stages of infection, aaMphi develop. In the present study, we used suppression subtractive hybridization (SSH) to identify genes that are expressed differentially in aaMphi versus caMphi elicited during infection with this T. b. brucei variant. We show that FIZZ1 and Ym1 are induced strongly in in vivo- and in vitro-elicited aaMphi as compared with caMphi. Furthermore, we demonstrate that the in vivo induction of FIZZ1 and Ym1 in macrophages depends on IL-4 and that in vitro, IFN-gamma antagonizes the effect of IL-4 on the expression of FIZZ1 and Ym1. Collectively, these results open perspectives for new insights into the functional properties of aaMphi and establish FIZZ1 and Ym1 as markers for aaMphi.
机译：替代地，活化的巨噬细胞（aaMphi）显示出不同于经典活化的巨噬细胞（caMphi）的分子和生物学特性。最近，我们描述了一种小鼠锥虫病的实验模型，其中布鲁氏锥虫锥虫感染小鼠的早期感染的特征是caMphi的发育，而在感染的晚期和慢性阶段，aaMphi会发育。在本研究中，我们使用抑制消减杂交（SSH）来鉴定在感染该T. b。期间在aaMphi与caMphi中差异表达的基因。布鲁西变种。我们显示，与caMphi相比，FIZZ1和Ym1在体内和体外诱导的aaMphi中被强烈诱导。此外，我们证明了巨噬细胞中FIZZ1和Ym1的体内诱导取决于IL-4，而在体外，IFN-γ拮抗IL-4对FIZZ1和Ym1表达的影响。总的来说，这些结果为aaMphi的功能特性的新见解开辟了前景，并确立了FIZZ1和Ym1作为aaMphi的标记。

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