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首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification.
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Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification.

机译：小胶质细胞，巨噬细胞，血管周围巨噬细胞和周细胞：功能和鉴定的综述。

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摘要

The phenotypic differentiation of systemic macrophages that have infiltrated the central nervous system, pericytes, perivascular macrophages, and the "real" resident microglial cells is a major immunocytochemical and immunohistochemical concern for all users of cultures of brain cells and brain sections. It is not only important in assessing the purity of cell cultures; it is also of fundamental importance in the assessment of the pathogenetic significance of perivascular inflammatory phenomena within the brain. The lack of a single membranous and/or biochemical marker allowing conclusive identification of these cells is still a major problem in neurobiology. This review briefly discusses the functions of these cells and catalogs a large number of membranous and biochemical markers, which can assist in the identification of these cells.
机译：已经渗透到中枢神经系统，周细胞，血管周巨噬细胞和“真正的”驻留小胶质细胞的全身巨噬细胞的表型分化是所有脑细胞和脑切片培养物使用者的主要免疫细胞化学和免疫组织化学关注。这不仅对评估细胞培养物的纯度很重要，而且在评估脑内血管周炎性现象的致病意义时，它也具有根本的重要性。缺少单个膜和/或生化标记物就不能确定地鉴定这些细胞仍然是神经生物学中的主要问题。这篇综述简要讨论了这些细胞的功能，并对大量的膜和生化标记进行了分类，这些标记可以帮助鉴定这些细胞。

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