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首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >Sepsis: rethinking the approach to clinical research.
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Sepsis: rethinking the approach to clinical research.

机译：败血症：重新思考临床研究方法。

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摘要

The clinical syndrome of sepsis encompasses a highly heterogeneous group of clinical disorders, varying with respect to the site, bacteriology, and even presence of infection and with the clinical syndrome evolving in the host. Clinical trials of strategies to modulate the host response that mediates sepsis were first initiated 25 years ago. A continuing record of disappointment has characterized subsequent work, and only a single new therapy has been licensed for clinical use. Yet, these commercial disappointments obscure a vibrant body of new knowledge that has clarified the biology of the innate immune response whose deranged expression is responsible for sepsis and that has provided important new insights into the failings of the traditional model of clinical research in sepsis. This review highlights advances in basic biology and underlines insights from clinical research that may point to new and more effective ways of translating an understanding of innate immunity into effective treatments for a leading cause of global morbidity and mortality.
机译：败血症的临床综合征包括高度异质的一组临床病症，其在部位，细菌学，甚至感染的存在方面有所不同，并且随着宿主中临床症状的发展而变化。调节介导败血症的宿主反应的策略的临床试验于25年前首次启动。令人失望的持续记录是其后续工作的特征，并且只有一种新疗法被许可用于临床。然而，这些商业上的失望掩盖了充满生机的新知识，这些新知识澄清了先天性免疫反应的生物学特性，其先天性表达异常导致败血症，并且为败血症中传统临床研究模型的失败提供了重要的新见识。这篇综述着重介绍了基础生物学的进展，并强调了来自临床研究的见识，这些见解可能指向了将对先天免疫的理解转化为有效治疗方法的新的更有效方法，从而成为全球发病率和死亡率的主要原因。

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