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首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >Gammadelta T cells mitigate the organ injury and mortality of sepsis.
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Gammadelta T cells mitigate the organ injury and mortality of sepsis.

机译：γT细胞减轻了器官损伤和败血症的死亡率。

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Sepsis is a difficult condition to treat and is associated with a high mortality rate. Sepsis is known to cause a marked depletion of lymphocytes, although the function of different lymphocyte subsets in the response to sepsis is unclear. gammadelta T cells are found largely in epithelial-rich tissues, and previous studies of gammadelta T cells in models of sepsis have yielded divergent results. In the present study, we examined the function of gammadelta T cells during sepsis in mice using cecal ligation and puncture (CLP). Mice deficient in gammadelta T cells had decreased survival times and increased tissue damage after CLP compared with wild-type mice. Furthermore, bacterial load was increased in gammadelta T cell-deficient mice, yet antibiotic treatment did not change mortality. Additionally, we found that recruitment of neutrophils and myeloid suppressor cells to the site of infection was diminished in gammadelta T cell-deficient mice. Finally, we found that circulating levels of IFN-gamma were increased, and systemic levels of IL-10 were decreased in gammadelta T cell-deficient mice after CLP compared with wild-type mice. gammadelta T cell-deficient mice also had increased intestinal permeability after CLP compared with wild-type mice. Neutralization of IFN-gamma abrogated the increase in intestinal permeability in gammadelta T cell-deficient mice. The intestines taken from gammadelta T cell-deficient mice had decreased myeloperoxidase yet had increased tissue damage as compared with wild-type mice. Collectively, our data suggest that gammadelta T cells modulate the response to sepsis and may be a potential therapeutic target.
机译：败血症是一种难以治疗的疾病，并与高死亡率相关。尽管尚不清楚脓毒症反应中不同淋巴细胞亚群的功能尚不清楚，但脓毒症可导致淋巴细胞明显耗竭。 γ-T细胞主要存在于上皮丰富的组织中，以前在脓毒症模型中对γ-T细胞的研究已产生了分歧的结果。在本研究中，我们使用盲肠结扎和穿刺（CLP）检查了小鼠败血症过程中γT细胞的功能。与野生型小鼠相比，CLP后缺乏γ-T细胞的小鼠的存活时间减少，组织损伤增加。此外，γ-δT细胞缺陷小鼠的细菌负荷增加，但是抗生素治疗并没有改变死亡率。此外，我们发现，在γδT细胞缺陷型小鼠中，嗜中性粒细胞和髓样抑制细胞募集到感染部位减少了。最后，我们发现，与野生型小鼠相比，CLP后γ-δT细胞缺陷型小鼠的循环中IFN-γ的水平升高，而IL-10的全身水平降低。与野生型小鼠相比，CLP后γδT细胞缺陷型小鼠的肠道通透性也增加。 IFN-γ的中和作用消除了γ-δT细胞缺陷小鼠肠道通透性的增加。与野生型小鼠相比，取自γδT细胞缺陷型小鼠的肠的髓过氧化物酶减少，但组织损伤增加。总体而言，我们的数据表明，γT细胞调节败血症的反应，可能是潜在的治疗靶点。

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