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首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >Molecular chaperones and protein-folding catalysts as intercellular signaling regulators in immunity and inflammation.
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Molecular chaperones and protein-folding catalysts as intercellular signaling regulators in immunity and inflammation.

机译：分子伴侣和蛋白质折叠催化剂作为免疫和炎症中的细胞间信号调节剂。

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摘要

This review critically examines the hypothesis that molecular chaperones and protein-folding catalysts from prokaryotes and eukaryotes can be secreted by cells and function as intercellular signals, principally but not exclusively, for leukocytes. A growing number of molecular chaperones have been reported to function as ligands for selected receptors and/or receptors for specific ligands. Molecular chaperones initially appeared to act primarily as stimulatory signals for leukocytes and thus, were seen as proinflammatory mediators. However, evidence is now emerging that molecular chaperones can have anti-inflammatory actions or, depending on the protein and concentration, anti- and proinflammatory functions. Recasting the original hypothesis, we propose that molecular chaperones and protein-folding catalysts are "moonlighting" proteins that function as homeostatic immune regulators but may also under certain circumstances, contribute to tissue pathology. One of the key issues in the field of molecular chaperone biology relates to the role of microbial contaminants in their signaling activity; this too will be evaluated critically. The most fascinating aspect of molecular chaperones probably relates to evidence for their therapeutic potential in human disease, and ongoing studies are evaluating this potential in a range of clinical settings.
机译：该评论严格审查了以下假设，即原核生物和真核生物的分子伴侣和蛋白质折叠催化剂可被细胞分泌，并起细胞间信号的作用，主要但不是专门针对白细胞。据报道，越来越多的分子伴侣起着所选受体的配体和/或特定配体的受体的作用。分子伴侣最初似乎主要充当白细胞的刺激信号，因此被视为促炎介质。但是，现在有证据表明分子伴侣可以具有抗炎作用，或者取决于蛋白质和浓度，具有抗炎和促炎作用。改写最初的假设，我们认为分子伴侣和蛋白质折叠催化剂是“月光下”的蛋白质，其起着稳态免疫调节剂的作用，但在某些情况下也可能有助于组织病理学。分子伴侣生物学领域的关键问题之一涉及微生物污染物在其信号传导活性中的作用。这也将进行严格评估。分子伴侣最令人着迷的方面可能与它们在人类疾病中的治疗潜力有关，目前正在进行的研究正在评估一系列临床环境中的这种潜力。

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